LEADER 03215nam 2200421z- 450 001 9910227346303321 005 20231214133322.0 035 $a(CKB)4100000000883870 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53830 035 $a(EXLCZ)994100000000883870 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Diagnostics in the Detection of Neurodegenerative Disorders 210 $cFrontiers Media SA$d2017 215 $a1 electronic resource (90 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-194-1 330 $aNeurodegeneration is characterized by the progressive loss of neural tissue that result in various neurodegeneration-initiated cerebral failures and complex diseases such as Alzheimer?s disease, Parkinson?s disease, Huntington?s disease. All these medical conditions are accompanied by the disruption of blood-brain barrier (BBB). The BBB is an interface, separating the brain from the circulatory system and protecting the central nervous system from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. Owing to the inability of the neurons to regenerate on their own after neurodegeneration or severe damage to the neural tissue, neurodegenerative disorders do not have natural cures on their own. Neuroregeneration is a viable way to curb neurodegeneration. One of the current approaches is stem cell-based therapy that has been shown to be potentially helpful for the application of neuronal cell replacement for neuroregeneration. It is vital that the neurodegenerative disorder being detected at an early stage as it can provide a chance for treatment that may be helpful to prevent further progression of the fatal disease. Thus, research has focused on developing effective non-invasive diagnostic methods for early detection of these disorders. Molecular diagnostics can provide a powerful method to detect and diagnose various neurological disorders. Such diagnosis can enhance early detection, provide subsequent medical counsel based on medical pathway, as well as to gain better insight of neurogenesis and hopefully eventual cure of the neurodegenerative diseases. With research reports, reviews, mini-reviews and commentary, this research topic covers a wide range of areas in neurodegeneration research, including diagnosis and prognosis; regulating central nervous system; biomarkers and brain injury induced neurobehavioral outcomes among other timely reports on neurodegeneration. 610 $aStem Cells 610 $aNeurodegenerative Diseases 610 $aNeuroprotection 610 $aNeurons 610 $abiomarkers 610 $aMicroRNAs 610 $aneurodegeneration 610 $adiagnosis 610 $aExosomes 610 $aHemorrhage 700 $aWilliam C. Cho$4auth$01287598 702 $aMegha Agrawal$4auth 906 $aBOOK 912 $a9910227346303321 996 $aMolecular Diagnostics in the Detection of Neurodegenerative Disorders$93020196 997 $aUNINA