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010   $a3-03842-521-4
035   $a(CKB)4100000000883893
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/49817
035   $a(EXLCZ)994100000000883893
100   $a20202102d2017      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aThe Identification of the Genetic Components of Autism Spectrum Disorders 2017
210   $cMDPI - Multidisciplinary Digital Publishing Institute$d2017
215   $a1 electronic resource (X, 462 p.)
311   $a3-03842-520-6 
330   $aThis textbook is dedicated to the study of genetic factors contributing to autism and includes a collection of original research and review articles related to this topic. Autism spectrum disorders (ASD) include a collection of neurodevelopmental disorders characterized by three recognized behavioral domains involving difficulties in communication, social interaction and repetitive behavior. ASD affects 1 to 2 percent of children and is on the increase worldwide. Significant genetic contributions and mechanisms underlie the causation of ASD. Advances in genetic technology and better awareness have led to a diagnosis of 50 to 70 percent of individuals with ASD primarily due to chromosomal abnormalities, submicroscopic deletions or duplications now identified with high-resolution microarray analysis, next-generation DNA (exome) sequencing of gene variants or mutations, recognized single gene disorders or metabolic disturbances. Through discovery by searching genomic databases and peer-reviewed research articles, nearly 800 genes have been identified to contribute to ASD. Highlights in the field of autism research, discovery and identification of genetic components with characterization will be addressed. Furthermore, reviews of current understanding of the causes and diagnostic approaches for ASD and related syndromes will be presented along with discussion of psychiatric/behavior comorbidities and related features, environmental risk factors, parental attitudes and treatment.
610   $agenetic
610   $atreatment
610   $agenes
610   $abiomarkers
610   $acopy number variants and mutations
610   $agenetic factors
610   $anext generation DNA exome sequencing and functional analysis
610   $aautism and autism spectrum disorders
610   $acausation and etiology
610   $areviews
610   $aneurodevelopment and physiology testing
610   $asyndromes
610   $aenvironmental risk factors
700   $aMerlin G. Butler (Ed.)$4auth$01304686
906   $aBOOK
912   $a9910227344003321
996   $aThe Identification of the Genetic Components of Autism Spectrum Disorders 2017$93027604
997   $aUNINA