LEADER 00774nam0-2200253 --450 001 9910226660303321 005 20171129131652.0 010 $a3540204571 100 $a20171114d2004----kmuy0itay5050 ba 101 0 $aeng 102 $aDE 105 $a 001yy 200 1 $aCollaborative planning in supply chains$ea negotiation-based approach$fGregor Dudek 210 $aBerlin [etc.]$cSpringer$dc2004 215 $aX, 234 p.$d24 cm 225 1 $aLecture notes in economics and mathematical systems$v533 700 1$aDudek,$bGregory$f<1958- >$0555063 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910226660303321 952 $aMXXXVI-A-34$fMAS 959 $aMAS 996 $aCollaborative planning in supply chains$91494939 997 $aUNINA LEADER 04692nam 22009015 450 001 9910299705703321 005 20200703223256.0 010 $a981-4585-08-4 024 7 $a10.1007/978-981-4585-08-8 035 $a(CKB)3710000000230899 035 $a(EBL)1968522 035 $a(OCoLC)907300525 035 $a(SSID)ssj0001353941 035 $a(PQKBManifestationID)11779897 035 $a(PQKBTitleCode)TC0001353941 035 $a(PQKBWorkID)11323375 035 $a(PQKB)10341561 035 $a(DE-He213)978-981-4585-08-8 035 $a(MiAaPQ)EBC1968522 035 $a(PPN)181349485 035 $a(EXLCZ)993710000000230899 100 $a20140908d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene /$fby Amita Kashyap, D. Bujamma, Naresh Babu M 205 $a1st ed. 2015. 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2015. 215 $a1 online resource (79 p.) 225 1 $aSpringerBriefs in Forensic and Medical Bioinformatics,$x2196-8845 300 $aDescription based upon print version of record. 311 $a981-4585-07-6 320 $aIncludes bibliographical references. 327 $aIntroduction -- Review of Literature -- Materials and Methods (Tools and Databases) -- Flowchart -- Conclusion.-References. 330 $aCancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10?30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken. 410 0$aSpringerBriefs in Forensic and Medical Bioinformatics,$x2196-8845 606 $aComputational intelligence 606 $aBioinformatics 606 $aCancer$xResearch 606 $aBiomedical engineering 606 $aMedical informatics 606 $aApplied mathematics 606 $aEngineering mathematics 606 $aComputational Intelligence$3https://scigraph.springernature.com/ontologies/product-market-codes/T11014 606 $aComputational Biology/Bioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/I23050 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aHealth Informatics$3https://scigraph.springernature.com/ontologies/product-market-codes/I23060 606 $aMathematical and Computational Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T11006 615 0$aComputational intelligence. 615 0$aBioinformatics. 615 0$aCancer$xResearch. 615 0$aBiomedical engineering. 615 0$aMedical informatics. 615 0$aApplied mathematics. 615 0$aEngineering mathematics. 615 14$aComputational Intelligence. 615 24$aComputational Biology/Bioinformatics. 615 24$aCancer Research. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aHealth Informatics. 615 24$aMathematical and Computational Engineering. 676 $a006.3 676 $a502.85 676 $a519 676 $a570285 700 $aKashyap$b Amita$4aut$4http://id.loc.gov/vocabulary/relators/aut$0720797 702 $aBujamma$b D$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aBabu M$b Naresh$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910299705703321 996 $aBioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene$92521956 997 $aUNINA