LEADER 01257nam0 22003013i 450 001 SUN0095946 005 20131105031718.389 100 $a20131105d1987 |0itac50 ba 101 $aita 102 $aIT 105 $a|||| ||||| 200 1 $aEconomia politica internazionale$fBruno S. Frey$ga cura di Paolo Guerrieri e Piercarlo Padoan 210 $a Milano$cAngeli$d1987 215 $a219 p.$d22 cm. 410 1$1001SUN0095951$12001 $aCollana di economia. Sez. 4$v25$1210 $aMilano$cAngeli. 620 $dMilano$3SUNL000284 700 1$aFrey$b, Bruno S.$3SUNV073605$0121764 702 1$aGuerrieri$b, Paolo$3SUNV003738 702 1$aPadoan$b, Pier Carlo$3SUNV003739 712 $aAngeli$3SUNV000073$4650 790 1$aPadoan, Pietro Carlo$zPadoan, Pier Carlo$3SUNV079743 790 1$aPadoan, Piercarlo$zPadoan, Pier Carlo$3SUNV079744 801 $aIT$bSOL$c20181109$gRICA 912 $aSUN0095946 950 $aUFFICIO DI BIBLIOTECA DEL DIPARTIMENTO DI ECONOMIA$d03 PREST IIIFb13 $e03 31217 995 $aUFFICIO DI BIBLIOTECA DEL DIPARTIMENTO DI ECONOMIA$bIT-CE0106$h31217$kPREST IIIFb13$op$qa 996 $aInternational political economics$948751 997 $aUNICAMPANIA LEADER 04598nam 2200421z- 450 001 9910220057803321 005 20210211 035 $a(CKB)3800000000216200 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42240 035 $a(oapen)doab42240 035 $a(EXLCZ)993800000000216200 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiology of Cognitive Aging: Model Systems, Technologies and Beyond 210 $cFrontiers Media SA$d2017 215 $a1 online resource (145 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-144-5 330 $aWelcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer's disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves "old" memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D.Welcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer's disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves "old" memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D. 517 $aBiology of Cognitive Aging 606 $aGenetics (non-medical)$2bicssc 610 $aage-related memory impairment 610 $aAlzheimer's disease 610 $aDementia 610 $aoutreach 610 $aParkinson's disease 610 $aPatients 610 $aSemi-automated system 615 7$aGenetics (non-medical) 700 $aShin Murakami$4auth$01287787 906 $aBOOK 912 $a9910220057803321 996 $aBiology of Cognitive Aging: Model Systems, Technologies and Beyond$93020389 997 $aUNINA