LEADER 01386nam2-2200409li-450 001 990000118610203316 005 20180312154708.0 010 $a0-8247-8302-6 035 $a0011861 035 $aUSA010011861 035 $a(ALEPH)000011861USA01 035 $a0011861 100 $a2001992101990-------y0itay0103----ba 101 0 $aeng 102 $aUS 200 1 $aAnalysis and partial defferential equations$ea collection of papers dedicated to Mischa Cotlar$fedited by Cora Sadosky 210 $aNew York$cMarcel Dekker$dcopyr. 1990 215 $aXXIII, 742 p.$cill.$d27 cm 225 2 $aLecture notes in pure and applied mathematics$v122 410 0$10010011859$12001$aLecture notes in pure and applied mathematics 610 1 $aanalisi funzionale 610 1 $aequazioni differenziali parziali 676 $a515$9Analisi matematica 702 1$aCotlar,$bMischa 702 1$aSadosky,$bCora 801 $aSistema bibliotecario di Ateneo dell' Università di Salerno$gRICA 912 $a990000118610203316 951 $a515 ANA$b14042/CBS$c515$d00220391 959 $aBK 969 $aSCI 979 $c19921013 979 $c20001110$lUSA01$h1711 979 $c20020403$lUSA01$h1619 979 $aPATRY$b90$c20040406$lUSA01$h1609 979 $aRSIAV7$b90$c20090506$lUSA01$h0905 996 $aAnalysis and partial defferential equations$91491059 997 $aUNISA LEADER 03753nam 2200361z- 450 001 9910220052803321 005 20231214133332.0 035 $a(CKB)3800000000216249 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/52069 035 $a(EXLCZ)993800000000216249 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aLuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria 210 $cFrontiers Media SA$d2016 215 $a1 electronic resource (122 p.) 225 1 $aFrontiers Research Topics 311 $a2-88919-917-7 330 $aThe most common quorum sensing (QS) system in Gram-negative bacteria occurs via N-acyl homoserine lactone (AHLs) signals. An archetypical system consists of a LuxI-family protein synthesizing the AHL signal which binds at quorum concentrations to the cognate LuxR-family transcription factors which then control gene expression by binding to specific sequences in target gene promoters. QS LuxR-family proteins are approximately 250 amino acids long and made up of two domains; at the N-terminus there is an autoinducer-binding domain whereas the C-terminus contains a DNA-binding helix-turn-helix (HTH) domain. QS LuxRs display surprisingly low similarities (18-25%) even if they respond to structurally similar AHLs. 95% of LuxRs share 9 highly conserved amino acid residues; six of these are hydrophobic or aromatic and form the cavity of the AHL-binding domain and the remaining three are in the HTH domain. With only very few exceptions, the luxI/R cognate genes of AHL QS systems are located adjacent to each other. The sequencing of many bacterial genomes has revealed that many proteobacteria also possess LuxRs that do not have a cognate LuxI protein associated with them. These LuxRs have been called orphans and more recently solos. LuxR solos are widespread in proteobacterial species that possess a canonical complete AHL QS system as well as in species that do not. In many cases more than one LuxR solo is present in a bacterial genome. Scientists are beginning to investigate these solos. Are solos responding to AHL signals? If present in a bacterium which possesses a canonical AHL QS system are solos an integral part of the regulatory circuit? Are LuxR solos eavesdropping on AHLs produced by neighboring bacteria? Have they evolved to respond to different signals instead of AHLs, and are these signals endogenously produced or exogenously provided? Are they involved in interkingdom signaling by responding to eukaryotic signals? Recent studies have revealed that LuxR solos are involved in several mechanisms of cell-cell communication in bacteria implicating them in bacterial intraspecies and interspecies communication as well as in interkingdom signaling by responding to molecules produced by eukaryotes. LuxR solos are likely to become major players in signaling since they are widespread among proteobacterial genomes and because initial studies highlight their different roles in bacterial communication. This Research Topic allows scientists studying or interested in LuxR solos to report their data and/or express their hypotheses and thoughts on this important and currently understudied family of signaling proteins. 610 $aLuxR solos 610 $aQuorum Sensing 610 $asignaling 610 $aAHL 610 $aBacteria 700 $aVittorio Venturi$4auth$01332393 702 $aBrian M.M. Ahmer$4auth 906 $aBOOK 912 $a9910220052803321 996 $aLuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria$93040933 997 $aUNINA