LEADER 02859nam  2200481z- 450 
001 9910220052303321
005 20210211
035   $a(CKB)3800000000216254
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42212
035   $a(oapen)doab42212
035   $a(EXLCZ)993800000000216254
100   $a20202102d2017      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aBioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges
210   $cFrontiers Media SA$d2017
215   $a1 online resource (95 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-096-1 
330   $aThe recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginning to be uncovered. Genetic and epigenetic aberrations affecting ncRNA gene sequences and their expression have been linked to a variety of pathological conditions, including cancer, cardiovascular and neurological diseases. Latest advances in the development of high throughput analysis techniques may help to shed light on the complex regulatory mechanisms in which ncRNA molecules are involved. Bioinformatics tools constitute a unique and essential resource for non-coding RNA studies, providing a powerful technology to organize, integrate and analyze the huge amount of data produced daily by wet biology experiments in order to discover patterns, identify relationships among heterogeneous biological elements and formulate functional hypotheses. This Research Topic reviews current knowledge, introduces novel methods, and discusses open challenges of this exciting and innovative field in connection with the most important biomedical applications. It consists of four reviews and six original research and methods articles, spanning the full scope of the Research Topic.
517   $aBioinformatics of Non-Coding RNAs with Applications to Biomedicine
606   $aBiotechnology$2bicssc
610   $abioinformatics
610   $aCLIPseq
610   $aCRISPR
610   $aisomiRs
610   $amicroRNA
610   $ancRNA
610   $anetworks
610   $aRNA Editing
610   $aRNAseq
610   $asiRNA
615  7$aBiotechnology
700   $aAlessandro Lagana$4auth$01312907
702   $aAlfredo Ferro$4auth
702   $aCarlo Maria Croce$4auth
906   $aBOOK
912   $a9910220052303321
996   $aBioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges$93031108
997   $aUNINA