LEADER 02109nam  2200421z- 450 
001 9910220051903321
005 20210211
035   $a(CKB)3800000000216258
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/52944
035   $a(oapen)doab52944
035   $a(EXLCZ)993800000000216258
100   $a20202102d2016      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aMechanisms of Innate Neuroprotection
210   $cFrontiers Media SA$d2016
215   $a1 online resource (138 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88919-929-0 
330   $aAs clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.
606   $aMedicine and Nursing$2bicssc
610   $aAlzheimer
610   $amiRNA
610   $aNCX
610   $aNeuroprotection
610   $apostconditioning
610   $apreconditioning
610   $aseizure
610   $aStroke
615  7$aMedicine and Nursing
700   $aGiuseppe Pignataro$4auth$01305930
906   $aBOOK
912   $a9910220051903321
996   $aMechanisms of Innate Neuroprotection$93028031
997   $aUNINA