LEADER 04008nam 2200481z- 450 001 9910220051703321 005 20210211 035 $a(CKB)3800000000216260 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/50091 035 $a(oapen)doab50091 035 $a(EXLCZ)993800000000216260 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aIn vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration 210 $cFrontiers Media SA$d2016 215 $a1 online resource (268 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-962-2 330 $aThe brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal migration can cause several neurological disorders, such as microcephaly, periventricular heterotopia and lissencephaly. Recent advances in genetic approaches to study the developing cerebral cortex, as well as the use of a number of novel techniques, particularly in vivo electroporation and time-lapse analyses using explant slice cultures, have significantly increased our understanding of cortical development. These novel techniques have allowed for cell biological analyses of cerebral cortical development in vivo or ex vivo, showing that many cellular events, including endocytosis, cell adhesion, microtubule and actin cytoskeletal regulation, neurotransmitter release, stress response, the consequence of cellular crowding (physical force), dynamics of transcription factors, midbody release and polarity transition are required for neurogenesis and/or neuronal migration. The aim of this research topic is to highlight molecular and cellular mechanisms underlying cerebral cortical development and its related neurological disorders from the cell biological point of views, such as cell division, cell-cycle regulation, cytoskeletal organization, cell adhesion and membrane trafficking. The topic has been organized into three chapters: 1) neurogenesis and cell fate determination, 2) neuronal migration and 3) cortical development-related neurological disorders. We hope that the results and discussions contributed by all authors in this research topic will be broadly useful for further advances in basic research, as well as improvements in the etiology and care of patients suffering from neurological and psychiatric disorders. 517 $aIn vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders 606 $aNeurosciences$2bicssc 610 $aCell Adhesion 610 $aCell Cycle 610 $aCell Division 610 $aCytoskeleton 610 $aEndocytosis 610 $aLissencephaly 610 $aMicrocephaly 610 $aNeurogenesis 610 $aneuronal migration 610 $aPeriventricular heterotopia 615 7$aNeurosciences 700 $aMargareta Nikolic$4auth$01305929 702 $aTakeshi Kawauchi$4auth 702 $aYoko Arai$4auth 906 $aBOOK 912 $a9910220051703321 996 $aIn vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration$93028030 997 $aUNINA