LEADER 03015nam  2200469z- 450 
001 9910220051303321
005 20210212
035   $a(CKB)3800000000216264
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/59232
035   $a(oapen)doab59232
035   $a(EXLCZ)993800000000216264
100   $a20202102d2016      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aSensory Hair Cell Death and Regeneration
210   $cFrontiers Media SA$d2016
215   $a1 online resource (266 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-000-7 
330   $aSensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future.
606   $aNeurosciences$2bicssc
610   $aauditory
610   $aCell Death
610   $aCochlea
610   $aHair cells
610   $aHearing Loss
610   $aNeuromast
610   $aOtic development
610   $aOtoprotection
610   $aototoxicity
610   $aRegeneration
615  7$aNeurosciences
700   $aMichael E. Smith$4auth$01284055
702   $aAllison B. Coffin$4auth
702   $aAndrew K. Groves$4auth
906   $aBOOK
912   $a9910220051303321
996   $aSensory Hair Cell Death and Regeneration$93019241
997   $aUNINA