LEADER 03028nam  2200409z- 450 
001 9910220049403321
005 20231214132846.0
035   $a(CKB)3800000000216283
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56244
035   $a(EXLCZ)993800000000216283
100   $a20202102d2016      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aThe Physiology and Pharmacology of Leucine-rich Repeat GPCRs
210   $cFrontiers Media SA$d2016
215   $a1 electronic resource (115 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-958-4 
330   $aG protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therapeutically, GPCRs represent a fertile source for the development of therapies as they are a significant percentage of our current pharmacopeia. Among the three subclasses of GPCRs, the Class A (rhodopsin-like) receptors are by far the most prevalent and extensively studied. However, within the Class A receptors, sub-families of receptors can be distinguished based upon common sequence motifs within the transmembrane domains as well as extracellular and intracellular domains. One such family of Class A receptors is characterized by multiple leucine- rich repeats within their amino- terminal domains (the Leucine-rich Repeat family (LRR)). This family of GPCRs are best represented by the glycoprotein hormone receptors (LHR, FSHR and TSHR) which have been studied extensively but also includes receptors for the peptide hormone relaxin (RXFP1 and RXFP2 (RXFP2 also binds insulin-like peptide 3)) and three other receptors (LGR4, LGR5 and LGR6). LGR4-6 were, until recently, considered orphan receptors. However, emerging data have revealed that these proteins are the receptors for a family of growth factors called R-spondins. Over the last 20 years much has been learned about LRR receptors, including the development of synthetic agonists and antagonists, new insights into signaling (including signaling bias) and the physiological role these receptors play in regulating the function of many tissues. This topic will focus on what is known concerning the regulation of these receptors, their signaling pathways, functional consequences of activation and pharmacology.
610   $aLeucine- rich repeat
610   $aTSH
610   $aGPCR
610   $aR-spondin
610   $aFSH
610   $aPharmacology
610   $aLH
610   $aRelaxin
610   $aLRR
700   $aBrian J. Arey$4auth$01329502
702   $aJames A. Dias$4auth
906   $aBOOK
912   $a9910220049403321
996   $aThe Physiology and Pharmacology of Leucine-rich Repeat GPCRs$93039523
997   $aUNINA