LEADER 02421nam 2200385z- 450 001 9910220048903321 005 20210211 035 $a(CKB)3800000000216288 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42415 035 $a(oapen)doab42415 035 $a(EXLCZ)993800000000216288 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBrain Injury as a Neurodegenerative Disorder 210 $cFrontiers Media SA$d2017 215 $a1 online resource (102 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-901-0 330 $aIt has been long assumed that following the resolution of acute injuries, traumatic brain injury represents a stable neural entity. However, there is growing evidence that a single moderate-severe brain injury may instead trigger an ongoing deteriorative process that commences sub-acutely, and occurs regardless of age. For scientists and clinicians, it is critical to examine this body of evidence and to explore its implications. Do the findings represent a neurodegenerative process or can they be alternatively explained? What are the neural, behavioural and functional characteristics of this progressive deterioration? Such information is needed to develop treatments to prevent or mitigate decline, and to inform the clinical care of brain injured patients. Research and clinical practice are influenced by the assumption that moderate-severe TBI is non-progressive, with few studies exploring treatments to prevent progression, and rehabilitation typically concentrated in the early stages of injury. Brain injuries can never be fully prevented. However, understanding that such progressive deterioration occurs opens a novel area of research - prevention of secondary decline - offering new possibilities for the improvement of long-term outcomes in people with traumatic brain injury. 606 $aNeurosciences$2bicssc 610 $aAtrophy 610 $achronic TBI 610 $achronic traumatic encephalopathy 610 $amoderate-severe TBI 610 $aneurodegeneration 615 7$aNeurosciences 700 $aRobin E.A. Green$4auth$01315287 906 $aBOOK 912 $a9910220048903321 996 $aBrain Injury as a Neurodegenerative Disorder$93032341 997 $aUNINA