LEADER 02495nam 2200469z- 450 001 9910220047903321 005 20210211 035 $a(CKB)3800000000216298 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40168 035 $a(oapen)doab40168 035 $a(EXLCZ)993800000000216298 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdrenal Cortex: From Physiology to Disease 210 $cFrontiers Media SA$d2016 215 $a1 online resource (89 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-919-3 330 $aThe adrenal gland plays essential roles in the control of body homeostasis, stress and immune responses. The adrenal cortex represents up to 90% of the gland and is specialised in the production of mineralocorticoids, glucocorticoids and adrenal androgens. This production is tightly coordinated and results from a unique zonal organisation. Although our knowledge of the molecular mechanisms controlling adrenal steroidogenesis is quite extensive, for decades, the mechanisms of adrenal cortex development, cellular homeostasis and renewal have remained elusive. The advent of new high-throughput technologies and sophisticated genetic approaches has brought tremendous progress in our understanding of how the adrenal cortex achieves and maintains its particular organisation. The aim of this Frontiers in Endocrinology Topic is to provide readers with a snapshot of our current knowledge on adrenal physiology and how deregulations of these processes result in adrenal diseases. This includes but is not limited to, basic research on adrenal development, cell lineage identification, progenitor cells, tissue renewal, control of differentiation and zonation and clinical research on the identification of disease-related genes. 517 $aAdrenal Cortex 606 $aMedicine and Nursing$2bicssc 610 $aAdenoma 610 $aadrenal 610 $aCancer 610 $adevelopment 610 $aDisease 610 $aHyperplasia 610 $aInsufficiency 610 $aPhysiology 610 $azonation 615 7$aMedicine and Nursing 676 $a612.4/5 702 $aMartinez$b Antoine$c(Microbiologist) 702 $aVal$b Pierre$f1976- 906 $aBOOK 912 $a9910220047903321 996 $aAdrenal cortex$93401607 997 $aUNINA