LEADER 01119nam--2200373---450- 001 990003444790203316 005 20100923133229.0 010 $a978-2-918887-01-0 035 $a000344479 035 $aUSA01000344479 035 $a(ALEPH)000344479USA01 035 $a000344479 100 $a20100923d2009----km-y0itay50------ba 101 $afre 102 $aIT 105 $a||||||||001yy 200 1 $aArtisanats antiques d'Italie et de Gaule$emélanges offerts à Maria Francesca Buonaiuto$fédités par Jean-Pierre Brun 210 $aNaples$cCentre Jean Bérard$d2009 215 $a316 p.$cill.$d30 cm 225 2 $aCollection du Centre Jean Bérard$v32 410 0$12001$aCollection du Centre Jean Bérard$v32 454 1$12001 461 1$1001-------$12001 606 0 $aArtigianato antico 676 $a745.5 702 1$aBRUN,$bJean-Pierre 801 0$aIT$bsalbc$gISBD 912 $a990003444790203316 951 $aHS 235$b11054 DSA 959 $aBK 969 $aDSA 979 $aDSA$b10$c20100923$lUSA01$h1332 996 $aArtisanats antiques d'Italie et de Gaule$9249971 997 $aUNISA LEADER 03645nam 2200445z- 450 001 9910220046103321 005 20210211 035 $a(CKB)3800000000216316 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48183 035 $a(oapen)doab48183 035 $a(EXLCZ)993800000000216316 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aFunction and Flexibility: Friend or Foe? 210 $cFrontiers Media SA$d2016 215 $a1 online resource (102 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-972-X 330 $aLouis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that "form follows function". When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that "function follows form" as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original "1 gene - 1 protein structure - 1 function" relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interacting with (a) partner molecule(s) are the most biologically relevant and in this context Sullivan's quote is still appropriate: the conformation that the protein adopts follows from the function of that protein. Despite the fact that many well-characterized proteins have a well-folded structure, there is a growing interest in the conformational flexibility within proteins. This flexibility is also a balanced phenomenon: excess of flexibility can be detrimental for protein behaviour, as well as the lack thereof. Notwithstanding its importance, studying intrinsically disordered protein regions or conformational rearrangements can be a very challenging. Therefore, flexibility can be perceived as a friend or a foe, depending on the context. This e-book showcases the impact of the study of protein flexibility on the structural biology field and presents protein flexibility in the context of disease as well as its benign aspects. As detailed knowledge of the structural aspects of polypeptides remains essential to comprehend protein function, one of the future challenges for structural biology also lies with large macromolecular protein complexes. Also there the dynamics and flexibility are essential for proper functioning and molecular movement, which is an important aspect of living matter. This challenge stimulated the development of advanced techniques to study protein flexibility and the use of those techniques to address fundamental biological and biomedical problems. Those innovations should help us to unravel the intimate link between protein function and flexibility and explore new horizons. 517 $aFunction and Flexibility 610 $aconformational ensemble 610 $aconformational selection and induced fit 610 $aintrinsically disordered proteins 610 $aProtein Conformation 610 $aProtein Disorder 610 $aprotein dynamics 610 $aprotein flexibility 610 $aProtein function 610 $aprotein structure 610 $aStructural transition 700 $aPeter Tompa$4auth$01292322 702 $aKris Pauwels$4auth 906 $aBOOK 912 $a9910220046103321 996 $aFunction and Flexibility: Friend or Foe$93022170 997 $aUNINA