LEADER 02741nam 2200445z- 450 001 9910220045703321 005 20210211 035 $a(CKB)3800000000216320 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48665 035 $a(oapen)doab48665 035 $a(EXLCZ)993800000000216320 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aGlial Plasticity in Depression 210 $cFrontiers Media SA$d2016 215 $a1 online resource (99 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-999-1 330 $aMajor depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment. 606 $aNeurosciences$2bicssc 610 $aantidepressant 610 $aastrocyte 610 $aDepression 610 $aMicroglia 610 $aNeuron 610 $aoligodendrocyte 615 7$aNeurosciences 700 $aLuisa Pinto$4auth$01315283 702 $aNuno Sousa$4auth 702 $aJoao F. Oliveira$4auth 702 $aCatarina A. Gomes$4auth 702 $aSandra H. Vaz$4auth 906 $aBOOK 912 $a9910220045703321 996 $aGlial Plasticity in Depression$93032337 997 $aUNINA