LEADER 05524nam 2200457z- 450 001 9910220045003321 005 20210211 035 $a(CKB)3800000000216327 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53603 035 $a(oapen)doab53603 035 $a(EXLCZ)993800000000216327 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMitochondria in Skeletal Muscle Health, Aging and Diseases 210 $cFrontiers Media SA$d2017 215 $a1 online resource (142 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-073-2 330 $aSkeletal muscle is the most abudant tissue of the human body, making up to 40 to 50% of the human body mass. While the importance of optimal muscle function is well recognized in the athletic field, its significance for general health is often underappreciated. In fact, the evidence that muscle mass, strength and metabolism are essential for our overall health is overwhelming. As the largest protein reservoir in the human body, muscles are essential in the acute response to critical illness such as sepsis, advanced cancer, and traumatic injury. Loss of skeletal muscle mass has also been associated with weakness, fatigue, insulin resistance, falls, fractures, frailty, disability, several chronic diseases and death. As a consequence, maintaining skeletal muscle mass, strength and metabolism throughout the lifespan is critical to the maintenance of whole body health. Mitochondria are fascinating organelles regulating many critical cellular processes for skeletal muscle physiology, including for instance energy supply, reactive oxygen species production, calcium homeostasis and the regulation of apoptosis. It is therefore not surprising that mitochondrial dysfunction has been implicated in a large number of adverse events/conditions and pathologies affecting skeletal muscle health. While the importance of normal mitochondrial function is well recognized for muscle physiology, there are important aspects of mitochondrial biology that are still poorly understood. These include mitochondrial dynamics (fusion and fission processes), morphology and processes involved in mitochondrial quality control (mitophagy). Defining the mechanisms regulating these different aspects of mitochondrial biology, their importance for muscle physiology, as well as the interrelations will be critical for expanding understanding of the role played by mitochondria in skeletal muscle physiology and health. The present research topic provides readers with novel experimental approaches, knowledge, hypotheses and findings related to all aspects of mitochondrial biology in healthy and diseased muscle cells.Skeletal muscle is the most abudant tissue of the human body, making up to 40 to 50% of the human body mass. While the importance of optimal muscle function is well recognized in the athletic field, its significance for general health is often underappreciated. In fact, the evidence that muscle mass, strength and metabolism are essential for our overall health is overwhelming. As the largest protein reservoir in the human body, muscles are essential in the acute response to critical illness such as sepsis, advanced cancer, and traumatic injury. Loss of skeletal muscle mass has also been associated with weakness, fatigue, insulin resistance, falls, fractures, frailty, disability, several chronic diseases and death. As a consequence, maintaining skeletal muscle mass, strength and metabolism throughout the lifespan is critical to the maintenance of whole body health. Mitochondria are fascinating organelles regulating many critical cellular processes for skeletal muscle physiology, including for instance energy supply, reactive oxygen species production, calcium homeostasis and the regulation of apoptosis. It is therefore not surprising that mitochondrial dysfunction has been implicated in a large number of adverse events/conditions and pathologies affecting skeletal muscle health. While the importance of normal mitochondrial function is well recognized for muscle physiology, there are important aspects of mitochondrial biology that are still poorly understood. These include mitochondrial dynamics (fusion and fission processes), morphology and processes involved in mitochondrial quality control (mitophagy). Defining the mechanisms regulating these different aspects of mitochondrial biology, their importance for muscle physiology, as well as the interrelations will be critical for expanding understanding of the role played by mitochondria in skeletal muscle physiology and health. The present research topic provides readers with novel experimental approaches, knowledge, hypotheses and findings related to all aspects of mitochondrial biology in healthy and diseased muscle cells. 606 $aPhysiology$2bicssc 610 $aAging 610 $aAtrophy 610 $aHypertrophy 610 $aMetabolism 610 $aMitochondria 610 $amitochondrial dynamics 610 $amitophagy 610 $amuscle contractility 610 $anutrition 610 $askeletal muscle 615 7$aPhysiology 700 $aGilles Gouspillou$4auth$01312905 702 $aRussell T. Hepple$4auth 906 $aBOOK 912 $a9910220045003321 996 $aMitochondria in Skeletal Muscle Health, Aging and Diseases$93031106 997 $aUNINA LEADER 01955nam 2200457z- 450 001 9910346722603321 005 20210211 010 $a1000042282 035 $a(CKB)4920000000094475 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42393 035 $a(oapen)doab42393 035 $a(EXLCZ)994920000000094475 100 $a20202102d2014 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBoundary-Layer Processes Producing Mesoscale Water-Vapour Variability over a Mountainous Island 210 $cKIT Scientific Publishing$d2014 215 $a1 online resource (242 S p.) 225 1 $aWissenschaftliche Berichte des Instituts für Meteorologie und Klimaforschung des Karlsruher Instituts für Technologie 311 08$a3-7315-0247-X 330 $aOver complex terrain, spatial inhomogeneities of pre-convective atmospheric conditions occur due to convection and mesoscale transport processes. This thesis focuses on the identification of these processes over the mountainous island of Corsica and on the evaluation of their impact on the spatial variability of water vapour, convection-related parameters and the evolution of deep convection by means of observations. 606 $aPhysics$2bicssc 610 $aAtmospha?rische Grenzschicht 610 $aAtmospheric boundary layer 610 $aConvection 610 $aCorsica 610 $aIntegrated Water Vapour 610 $aIntegrierter Wasserdampfgehalt 610 $aKonvektion 610 $aKorsika 610 $aThermally driven circulation 610 $aThermische Zirkulation 615 7$aPhysics 700 $aAdler$b Bianca$4auth$01319352 906 $aBOOK 912 $a9910346722603321 996 $aBoundary-Layer Processes Producing Mesoscale Water-Vapour Variability over a Mountainous Island$93033813 997 $aUNINA