LEADER 02907nam 2200385z- 450 001 9910220043003321 005 20231214133421.0 035 $a(CKB)3800000000216347 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/46856 035 $a(EXLCZ)993800000000216347 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEssential Pathways and Circuits of Autism Pathogenesis 210 $cFrontiers Media SA$d2016 215 $a1 electronic resource (181 p.) 225 1 $aFrontiers Research Topics 311 $a2-88919-905-3 330 $aThe Centers for Disease Control and Prevention estimate that 1 in 68 children in the United states is afflicted with autism spectrum disorders (ASD), yet at this time, there is no cure for the disease. Autism is characterized by delays in the development of many basic skills, most notably the ability to socialize and adapt to novelty. The condition is typically identified in children around 3 years of age, however the high heritability of autism suggests that the disease process begins at conception. The identification of over 500 ASD risk genes, has enabled the molecular genetic dissection of the pathogenesis of the disease in model organisms such as mice. Despite the genetic heterogeneity of ASD etiology, converging evidence suggests that these disparate genetic lesions may result in the disruption of a limited number of key biochemical pathways or circuits. Classification of patients into groups by pathogenic rather than etiological categories, will likely aid future therapeutic development and clinical trials. In this set of papers, we explore the existing evidence supporting this view. Specifically, we focus on biochemical cascades such as mTOR and ERK signaling, the mRNA network bound by FMRP and UBE3A, dorsal and ventral striatal circuits, cerebellar circuits, hypothalamic projections, as well as prefrontal and anterior cingulate cortical circuits. Special attention will be given to studies that demonstrate the necessity and/or sufficiency of genetic disruptions (e.g. by molecular deletion and/or replacement) in these pathways and circuits for producing characteristic behavioral features of autism. Necessarily these papers will be heavily weighted towards basic mechanisms elucidated in animal models, but may also include investigations in patients. 610 $aCerebellum 610 $aStriatum 610 $aOxytocin 610 $amTOR 610 $aHypothalamus 610 $aNeurodevelopmental disorders 610 $aCell signaling 700 $aGul Dolen$4auth$01331049 702 $aMustafa Sahin$4auth 906 $aBOOK 912 $a9910220043003321 996 $aEssential Pathways and Circuits of Autism Pathogenesis$93040073 997 $aUNINA