LEADER 02521nam  2200373z- 450 
001 9910220041503321
005 20231214133411.0
035   $a(CKB)3800000000216362
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40958
035   $a(EXLCZ)993800000000216362
100   $a20202102d2016      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAntifungal Drug Discovery: New Theories and New Therapies
210   $cFrontiers Media SA$d2016
215   $a1 electronic resource (136 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-950-9 
330   $aFungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.
517   $aAntifungal Drug Discovery
610   $aResistance
610   $aAntimycotics
610   $aCandida
610   $aMycoses
610   $aantifungals
700   $aChaminda Jayampath Seneviratne$4auth$01296302
702   $aEdvaldo Antonio Ribeiro Rosa$4auth
906   $aBOOK
912   $a9910220041503321
996   $aAntifungal Drug Discovery: New Theories and New Therapies$93023976
997   $aUNINA