LEADER 02643nam 2200421z- 450 001 9910220041203321 005 20210211 035 $a(CKB)3800000000216365 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/49645 035 $a(oapen)doab49645 035 $a(EXLCZ)993800000000216365 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aHuman Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins 210 $cFrontiers Media SA$d2016 215 $a1 online resource (97 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-961-4 330 $aTP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation. 517 $aHuman Tumor-Derived p53 Mutants 606 $aMedicine$2bicssc 610 $adominant netagive 610 $again of function 610 $amouse models 610 $amutant p53 610 $aOncogenic addiction 610 $atherapies 615 7$aMedicine 700 $aGiovanni Blandino$4auth$044946 702 $aYgal Haupt$4auth 906 $aBOOK 912 $a9910220041203321 996 $aHuman Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins$93040071 997 $aUNINA