LEADER 02576nam  2200445z- 450 
001 9910220038903321
005 20231214132842.0
035   $a(CKB)3800000000216388
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54099
035   $a(EXLCZ)993800000000216388
100   $a20202102d2017      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMuscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms
210   $cFrontiers Media SA$d2017
215   $a1 electronic resource (104 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-103-8 
330   $aAging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopaedics in human and in animal models. The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions.
517   $aMuscle-Tendon-Innervation Unit
610   $aNanoparticles
610   $acongenital muscular dystrophy
610   $aStem/progenitor cells
610   $atherapy
610   $aAging
610   $aParkinson's camptocormia
610   $aMuscle
610   $ainnervation
610   $aAnimal Models
610   $aTendon
700   $aPaolo Bonaldo$4auth$01322469
702   $aCesare Faldini$4auth
702   $aLuciano Merlini$4auth
906   $aBOOK
912   $a9910220038903321
996   $aMuscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms$93040509
997   $aUNINA