LEADER 02870nam  2200373z- 450 
001 9910220038803321
005 20231214132830.0
035   $a(CKB)3800000000216389
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/50013
035   $a(EXLCZ)993800000000216389
100   $a20202102d2017      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aThe Impact of Systems Medicine on Human Health and Disease
210   $cFrontiers Media SA$d2017
215   $a1 electronic resource (96 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-140-2 
330   $aComplex diseases including diabetes, neurological disorders and cancer are results from a combination of genetic, environmental and lifestyle factors, and development of new prognostic tools for the treatment of such diseases requires a deep understanding of the mechanisms underlying cell functions. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties. This inter-disciplinary field of study allows for understanding biological processes of cells in health and disease states, gaining new insights into what drives the appearance of the disease and finally identifying proteins and metabolites implicated in human disease. Systems medicine utilizes mathematical approaches to generate models which can be employed for designing new sets of experiments and for mapping the response of the system to perturbations quantitatively. These models, as well as the developed tools, can accelerate the emergence of personalized medicine which can transform the practice of medicine and offer better targets for drug development with minimum side effects. In this Research Topic, we aim to review the recently developed tools for modeling the cell behavior in normal and pathological states, recent advances and findings which increase our understanding of the molecular mechanisms involved in the progression of the diseases.
610   $aMetabolic Networks and Pathways
610   $aNetworks medicine
610   $aMetabolic Diseases
610   $aSystems Medicine
610   $aSystems Biology
610   $abiological networks
700   $aAdil Mardinoglu$4auth$01285368
702   $aJens Nielsen$4auth
906   $aBOOK
912   $a9910220038803321
996   $aThe Impact of Systems Medicine on Human Health and Disease$93019547
997   $aUNINA