LEADER 02933nam  2200433z- 450 
001 9910220038403321
005 20231214132837.0
035   $a(CKB)3800000000216393
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/46422
035   $a(EXLCZ)993800000000216393
100   $a20202102d2016      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aEngineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices
210   $cFrontiers Media SA$d2016
215   $a1 electronic resource (130 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-921-5 
330   $aThe discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies.
517   $aEngineering Synthetic Metabolons
610   $aMetabolic Engineering
610   $areconstitution
610   $amolecular dynamics simulations
610   $aMembrane Transport Proteins
610   $aProtein Engineering
610   $aProtein scaffolds
610   $ametabolite profiling
610   $aInteraction domains
610   $aMetabolic Modelling
610   $aStarch biosynthesis
700   $aZoran Nikoloski$4auth$01303433
702   $aLars M. Voll$4auth
906   $aBOOK
912   $a9910220038403321
996   $aEngineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices$93027037
997   $aUNINA