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035   $a(CKB)3800000000216408
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61392
035   $a(EXLCZ)993800000000216408
100   $a20202102d2017      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aTumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics
210   $cFrontiers Media SA$d2017
215   $a1 electronic resource (113 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-064-3 
330   $aHypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.
517   $aTumor Hypoxia
610   $amicroenvironment
610   $aStem Cells
610   $ahypoxia
610   $astress
610   $aHIF
610   $atumor
610   $aLeukemia
610   $abiomarkers
610   $atherapy
610   $apH
700   $aChristian R. Gomez$4auth$01296299
906   $aBOOK
912   $a9910220036903321
996   $aTumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics$93023973
997   $aUNINA