LEADER 03057nam 2200457z- 450 001 9910220036503321 005 20210212 035 $a(CKB)3800000000216412 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57927 035 $a(oapen)doab57927 035 $a(EXLCZ)993800000000216412 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aReelin-Related Neurological Disorders and Animal Models 210 $cFrontiers Media SA$d2017 215 $a1 online resource (179 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-111-9 330 $aThe Reeler mutation was so named because of the alterations in gait that characterize homozygous mice. Several decades after the description of the Reeler phenotype, the mutated protein was discovered and named Reelin (Reln). Reln controls a number of fundamental steps in embryonic and postnatal brain development. A prominent embryonic function is the control of radial neuronal migration. As a consequence, homozygous Reeler mutants show disrupted cell layering in cortical brain structures. Reln also promotes postnatal neuronal maturation. Heterozygous mutants exhibit defects in dendrite extension and synapse formation, correlating with behavioral and cognitive deficits that are detectable at adult ages. The Reln-encoding gene is highly conserved between mice and humans. In humans, homozygous RELN mutations cause lissencephaly with cerebellar hypoplasia, a severe neuronal migration disorder that is reminiscent of the Reeler phenotype. In addition, RELN deficiency or dysfunction is also correlated with psychiatric and cognitive disorders, such as schizophrenia, bipolar disorder and autism, as well as some forms of epilepsy and Alzheimer's disease. Despite the wealth of anatomical studies of the Reeler mouse brain, and the molecular dissection of Reln signaling mechanisms, the consequences of Reln deficiency on the development and function of the human brain are not yet completely understood. This Research Topic include reviews that summarize our current knowledge of the molecular aspects of Reln function, original articles that advance our understanding of its expression and function in different brain regions, and reviews that critically assess the potential role of Reln in human psychiatric and cognitive disorders. 606 $aNeurosciences$2bicssc 610 $aautism 610 $aDepression 610 $aintracellular pathways 610 $aNeuronal Death 610 $aneuronal migration 610 $aNeurons 610 $aReeler 610 $aSchizophrenia 610 $aSynapses 615 7$aNeurosciences 700 $aLaura Lossi$4auth$01331046 702 $aAdalberto Merighi$4auth 702 $aGabriella D'Arcangelo$4auth 906 $aBOOK 912 $a9910220036503321 996 $aReelin-Related Neurological Disorders and Animal Models$93040068 997 $aUNINA