LEADER 02303nam  2200469z- 450 
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035   $a(CKB)3800000000216424
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53863
035   $a(oapen)doab53863
035   $a(EXLCZ)993800000000216424
100   $a20202102d2017      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aMolecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease
210   $cFrontiers Media SA$d2017
215   $a1 online resource (183 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-173-9 
330   $aThe advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants.
606   $aNeurosciences$2bicssc
610   $aAmyotrophic Lateral Sclerosis
610   $aGABA-A receptor
610   $aglycine receptor
610   $aInflammation
610   $aIntellectual Disability
610   $aLRRK2
610   $aNMDA receptors
610   $aParkinson's disease
610   $aPET imaging
610   $aStem Cells
610   $aZebrafish
615  7$aNeurosciences
700   $aRobert J. Harvey$4auth$01278463
702   $aKirsten Harvey$4auth
906   $aBOOK
912   $a9910220035303321
996   $aMolecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease$93013298
997   $aUNINA