LEADER 02009nas 22005053a 450 001 996279993603316 005 20220212213022.0 011 $a2158-3927 035 $a(OCoLC)606602700 035 $a(CKB)991042723555596 035 $a(CONSER)--2010203491 035 $a(EXLCZ)99991042723555596 100 $a20100411a20009999 --- a 101 0 $aeng 135 $aurbn||||||abp 135 $aurbn||||||ada 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProceedings /$fInternational Conference on Dependable Systems and Networks ; sponsored by IEEE Computer Society Technical Committee on Fault-Tolerant Computing, IFIP Working Group 10.4 on Dependable Computing and Fault Tolerance ; in cooperation with AT & T [and others] 210 $aLos Alamitos, CA $cIEEE Computer Society 311 $a1530-0889 517 1 $aProceedings of the ... International Conference on Dependable Systems and Networks 517 1 $aDSN 517 3 $aInternational Conference on Dependable Systems and Networks 517 3 $aIEEE/IFIP International Conference on Dependable Systems and Networks 531 $aIEEE INTERNATIONAL CONFERENCE ON DEPENDABLE SYSTEMS AND NETWORKS 531 0 $aProc. 606 $aFault-tolerant computing$vCongresses 606 $aApplication software$vCongresses 606 $aApplication software$2fast$3(OCoLC)fst00811706 606 $aFault-tolerant computing$2fast$3(OCoLC)fst00921988 608 $aConference papers and proceedings.$2fast 615 0$aFault-tolerant computing 615 0$aApplication software 615 7$aApplication software. 615 7$aFault-tolerant computing. 676 $a004 676 $a004 712 02$aIEEE Computer Society.$bFault-Tolerant Computing Technical Committee. 712 02$aIFIP Working Group 10.4 on Dependable Computing and Fault Tolerance. 906 $aCONFERENCE 912 $a996279993603316 996 $aProceedings$957126 997 $aUNISA LEADER 02303nam 2200469z- 450 001 9910220035303321 005 20210211 035 $a(CKB)3800000000216424 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53863 035 $a(oapen)doab53863 035 $a(EXLCZ)993800000000216424 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease 210 $cFrontiers Media SA$d2017 215 $a1 online resource (183 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-173-9 330 $aThe advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants. 606 $aNeurosciences$2bicssc 610 $aAmyotrophic Lateral Sclerosis 610 $aGABA-A receptor 610 $aglycine receptor 610 $aInflammation 610 $aIntellectual Disability 610 $aLRRK2 610 $aNMDA receptors 610 $aParkinson's disease 610 $aPET imaging 610 $aStem Cells 610 $aZebrafish 615 7$aNeurosciences 700 $aRobert J. Harvey$4auth$01278463 702 $aKirsten Harvey$4auth 906 $aBOOK 912 $a9910220035303321 996 $aMolecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease$93013298 997 $aUNINA