LEADER 02704nam 2200385z- 450 001 9910220034503321 005 20210211 035 $a(CKB)3800000000216432 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48864 035 $a(oapen)doab48864 035 $a(EXLCZ)993800000000216432 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aGrappling with the Multifaceted World of the DNA Damage Response 210 $cFrontiers Media SA$d2017 215 $a1 online resource (306 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-057-0 330 $aDNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes. 606 $aGenetics (non-medical)$2bicssc 610 $aDNA Damage 610 $aDNA damage response 610 $aDNA Repair 610 $agenome instability 610 $aGenome integrity 615 7$aGenetics (non-medical) 700 $aAntonio Porro$4auth$01277577 906 $aBOOK 912 $a9910220034503321 996 $aGrappling with the Multifaceted World of the DNA Damage Response$93011659 997 $aUNINA