LEADER 04522nam 22006974a 450 001 9911019704803321 005 20200520144314.0 010 $a9786610274062 010 $a9781280274060 010 $a1280274069 010 $a9780470871614 010 $a047087161X 010 $a9780470871621 010 $a0470871628 035 $a(CKB)111087027098534 035 $a(EBL)219736 035 $a(SSID)ssj0000161463 035 $a(PQKBManifestationID)11183409 035 $a(PQKBTitleCode)TC0000161463 035 $a(PQKBWorkID)10199258 035 $a(PQKB)10363702 035 $a(MiAaPQ)EBC219736 035 $a(OCoLC)54511024 035 $a(Perlego)2760826 035 $a(EXLCZ)99111087027098534 100 $a20030724d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGeneration and effector functions of regulatory lymphocytes /$f[editors, Gregory Bock and Jamie Goode] 210 $aHoboken, N.J. $cWiley$dc2003 215 $a1 online resource (327 p.) 225 1 $aNovartis Foundation symposium ;$v252 300 $aDescription based upon print version of record. 311 08$a9780470850749 311 08$a0470850744 320 $aIncludes bibliographical references and index. 327 $aGENERATION AND EFFECTOR FUNCTIONS OF REGULATORY LYMPHOCYTES; Contents; Participants; Chair's introduction; Thymic generation and selection of CD25(+)CD4(+) regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance; Discussion; Control of T cell activation by CD4(+)CD25(+) suppressor T cells; Discussion; Regulation of experimental autoimmune encephalomyelitis (EAE) by CD4(+)CD25(+) regulatory T cells; Discussion; The role of CD28 and CTLA4 in the function and homeostasis of CD4(+)CD25(+) regulatory T cells 327 $aDiscussionCD4(+)CD25(+) regulatory cells from human peripheral blood express very high levels of CD25 ex vivo; Discussion; Control of immune pathology by regulatory T cells; Discussion; General discussion I TGFB; Type 1 T regulatory cells and their relationship with CD4(+)CD25(+) T regulatory cells; Discussion; (PRO)insulin-specific regulatory T cells; Discussion; CD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into the mechanisms of protection against Type 1 diabetes; Discussion 327 $aSeven surprises in the TCR-centred regulation of immune responsiveness in an autoimmune systemDiscussion; Regulatory cells in transplantation; Discussion; CD4(+) regulatory T cells in chronic viral infection; Discussion; General discussion II; Modulation of T cell responses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship; Discussion; Dendritic cells: controllers of the immune system and a new promise for immunotherapy; Discussion; Regulation of viral and autoimmune responses; Discussion; General discussion III Active immune regulation 327 $aNotch signalling in the peripheral immune systemDiscussion; CD3 antibody treatment stimulates the functional capability of regulatory T cells; Discussion; The role of dendritic cells in regulating mucosal immunity and tolerance; Discussion; Index of contributors; Subject index 330 $aOver the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions are 410 0$aNovartis Foundation symposium ;$v252. 606 $aLymphocytes 606 $aT cells 606 $aImmune response$xRegulation 615 0$aLymphocytes. 615 0$aT cells. 615 0$aImmune response$xRegulation. 676 $a571.9/6 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019704803321 996 $aGeneration and effector functions of regulatory lymphocytes$94417569 997 $aUNINA LEADER 02521oam 2200613zu 450 001 9910219981103321 005 20230720213158.0 010 $a0-8330-8323-6 035 $a(CKB)2560000000315324 035 $a(SSID)ssj0001048538 035 $a(PQKBManifestationID)12440333 035 $a(PQKBTitleCode)TC0001048538 035 $a(PQKBWorkID)11014623 035 $a(PQKB)11229017 035 $a(PPN)270194959 035 $a(oapen)doab115192 035 $a(EXLCZ)992560000000315324 100 $a20160829d2013 uy 101 0 $aeng 135 $aurmn|---annan 181 $ctxt 182 $cc 183 $acr 200 10$aAdapting the Army's training and leader development programs for future challenges 210 $cRAND Corporation$d2013 210 31$a[Place of publication not identified]$cRand Arroyo Center$d2013 215 $a1 online resource 225 0 $aTechnical report Adapting the Army's training and leader development programs for future challenges 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a0-8330-7638-8 330 $aIn addition to the defeat of conventional enemy forces, Army units and leaders must be able to defeat unconventional forces, develop partner forces, protect local populations, and support civil functions. This report examines the adequacy of the Army Training and Leader Development (ATLD) system management processes, identifies areas for improvement, and develops directions that the Army could take to improve its ATLD management processes. 606 $aCommand of troops$xStudy and teaching$zUnited States 606 $aLeadership$xStudy and teaching$zUnited States 606 $aMilitary education$zUnited States 606 $aMilitary & Naval Science$2HILCC 606 $aLaw, Politics & Government$2HILCC 606 $aMilitary Administration$2HILCC 615 0$aCommand of troops$xStudy and teaching 615 0$aLeadership$xStudy and teaching 615 0$aMilitary education 615 7$aMilitary & Naval Science 615 7$aLaw, Politics & Government 615 7$aMilitary Administration 676 $a355.5/50973 700 $aCrowley$b James C$0846322 702 $aSollinger$b Jerry M. 702 $aShanley$b Michael G 702 $aRothenberg$b Jeff 712 02$aArroyo Center, 801 0$bPQKB 906 $aBOOK 912 $a9910219981103321 996 $aAdapting the Army's training and leader development programs for future challenges$92878771 997 $aUNINA