LEADER 02990nam 2200469z- 450 001 9910166646303321 005 20210211 035 $a(CKB)3710000001092136 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42564 035 $a(oapen)doab42564 035 $a(EXLCZ)993710000001092136 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCa2+ Signaling and Heart Rhythm 210 $cFrontiers Media SA$d2016 215 $a1 online resource (133 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-874-X 330 $aCa2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regulatory processes occur simultaneously within a cell. Yet, distinct signals can be resolved by local Ca2+ sensitive protein complexes and differential Ca2+ signal integration. In addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. Ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular Ca overloading. Recent studies also implicate Ca2+ in Na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. At the cellular level, such regulation involves control of the activity of membrane ion channels and Ca2+ handling proteins. These in turn involve multiple extra- and intracellular signaling pathways. This e-book assembles review and original articles from experts in this field. It summarises major recent progress bearing on roles of Ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. These extend from physiological roles of Ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal Ca2+ signaling in both atrial and ventricular arrhythmogenesis. It also seeks to bridge the gap between advances in basic science and development of new therapies. 606 $aPhysiology$2bicssc 610 $aCa2+ 610 $aHeart 610 $aOrai1 610 $aPak1 610 $aPP2A 610 $aSA node 610 $aSTIM1 610 $aTRPC 610 $avoltage gated Ca2+ channels 615 7$aPhysiology 700 $aChristopher L.-H. Huang$4auth$01277604 702 $aYunbo Ke$4auth 702 $aR. John Solaro$4auth 702 $aMing Lei$4auth 906 $aBOOK 912 $a9910166646303321 996 $aCa2+ Signaling and Heart Rhythm$93011710 997 $aUNINA