LEADER 03148nam  2200481z- 450 
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035   $a(CKB)3710000001092140
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58607
035   $a(oapen)doab58607
035   $a(EXLCZ)993710000001092140
100   $a20202102d2016      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aRole of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease
210   $cFrontiers Media SA$d2016
215   $a1 online resource (220 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88919-866-9 
330   $aAdult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
606   $aNeurosciences$2bicssc
610   $aageing
610   $aepigenetics
610   $afibrosis
610   $amuscle wasting
610   $amuscular dystrophies
610   $amyogenesis
610   $apericytes
610   $arejuvenation
610   $asarcopenia
610   $asatellite cell
615  7$aNeurosciences
700   $aPura Munoz-Canoves$4auth$01279433
702   $aJaime J. Carvajal$4auth
702   $aAdolfo Lopez de Munain$4auth
702   $aAnder Izeta$4auth
906   $aBOOK
912   $a9910166645903321
996   $aRole of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease$93015372
997   $aUNINA