LEADER 03831nam 2200469 450 001 9910822925903321 005 20230807201927.0 010 $a0-309-37648-3 010 $a0-309-37646-7 035 $a(CKB)3710000000513378 035 $a(EBL)4393802 035 $a(MiAaPQ)EBC4393802 035 $a(Au-PeEL)EBL4393802 035 $a(CaPaEBR)ebr11163290 035 $a(OCoLC)928070329 035 $a(EXLCZ)993710000000513378 100 $a20160318h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aSupport for forensic science research $eimproving the scientific role of the National Institute of Justice /$fCommittee on Strengthening Forensic Science at the National Institute of Justice 210 1$aWashington, District of Columbia :$cThe National Academies Press,$d2015. 210 4$dİ2015 215 $a1 online resource (116 p.) 300 $aDescription based upon print version of record. 311 $a0-309-37645-9 320 $aIncludes bibliographical references. 327 $aFrontMatter; Preface; Acknowledgments; Contents; Figures, Tables, and Boxes; Acronyms; Summary; 1 Introduction; 2 Forensic Science in the United States; 3 Research Operations of the National Institute of Justice; 4 Forensic Science Research at NIJ: A Blueprint for the Future; References; Appendixes; Appendix A: Speakers; Appendix B: Previous Report Recommendations; Appendix C: Committee Questions to NIJ; Appendix D: Biographical Sketches of Committee Members 330 $a"Reliable and valid forensic science analytic techniques are critical to a credible, fair, and evidence-based criminal justice system. There is widespread agreement that the scientific foundation of some currently available forensic science methods needs strengthening and that additional, more efficient techniques are urgently needed. These needs can only be met through sustained research programs explicitly designed to ensure and improve the reliability and validity of current methods and to foster the development and use of new and better techniques. This task is challenging due to the broad nature of the field. Concerns have been raised repeatedly about the ability of the criminal justice system to collect and analyze evidence efficiently and to be fair in its verdicts. Although significant progress has been made in some forensic science disciplines, the forensic science community still faces many challenges. Federal leadership, particularly in regard to research and the scientific validation of forensic science methods, is needed to help meet the pressing issues facing state and local jurisdictions. This report reviews the progress made by the National Institute of Justice (NIJ) to advance forensic science research since the 2009 report, Strengthening Forensic Science in the United States: A Path Forward and the 2010 report, Strengthening the National Institute of Justice. Support for Forensic Science Research examines the ways in which NIJ develops its forensic science research priorities and communicates those priorities as well as its findings to the scientific and forensic practitioner communities in order to determine the impact of NIJ forensic science research programs and how that impact can be enhanced"--Publisher's description 606 $aForensic sciences$zUnited States$xEvaluation 615 0$aForensic sciences$xEvaluation. 676 $a364.973 712 02$aNational Academies of Sciences, Engineering, and Medicine (U.S.).$bDivision of Behavioral and Social Sciences and Education. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910822925903321 996 $aSupport for forensic science research$93971197 997 $aUNINA LEADER 02442nam 2200373z- 450 001 9910166644803321 005 20210211 035 $a(CKB)3710000001092151 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53858 035 $a(oapen)doab53858 035 $a(EXLCZ)993710000001092151 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular Regulation and Therapeutic Potential of Thermogenic Fat Cells 210 $cFrontiers Media SA$d2016 215 $a1 online resource (127 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-869-3 330 $aObesity has emerged as a major threat to public health in both the western and developing world. Essentially a disorder of energy balance, obesity occurs when energy intake and storage exceeds expenditure. Much of energy homeostasis depends on the activity and function of adipose tissue. Adipocytes in mammals fall into two categories classified by their primary functions: white fat cells that mediate energy storage and thermogenic fat cells that counteract hypothermia and obesity through adaptive thermogenesis. Whereas white fat and its function as an energy reservoir and endocrine organ have been studied for decades and are relatively well understood, until recently many aspects of the thermogenic fat biology have remained elusive. Accumulating evidence supports the hypothesis that thermogenic fat cells arise from at least two different developmental origins: the ones of a skeletal muscle-like lineage are now called "classical" brown fat cells, and the rest of the thermogenic fat cells are normally referred to as the beige fat cells. The last decade has witnessed an explosion of interest and studies focusing on the regulation of thermogenic fat cells and potential therapeutics targeting these adipocytes. Here we summarize the recent advancements in our understanding of these metabolically active fat cells. 610 $aadaptive thermogenesis 610 $abeige fat 610 $aBrown Fat 610 $aEnergy Metabolism 610 $ametabolic disease 610 $aObesity 700 $aJun Wu$4auth$01277586 906 $aBOOK 912 $a9910166644803321 996 $aMolecular Regulation and Therapeutic Potential of Thermogenic Fat Cells$93011672 997 $aUNINA