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024 7 $a10.1007/978-3-319-50693-7
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035   $a(DE-He213)978-3-319-50693-7
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100   $a20170209d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aFree Fatty Acid Receptors /$fedited by Graeme Milligan, Ikuo Kimura
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (VIII, 256 p. 70 illus.) 
225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v236
311   $a3-319-50692-7 
311   $a3-319-50693-5 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aLigands at Free Fatty Acid Receptor 1 (GPR40) -- Ligands at Free Fatty Acid Receptor 2/3 (GPR43)/GPR41 -- Ligands at GPR84 -- Ligands at Free Fatty Acid Receptor 4 (GPR120) -- Homology modelling of FFA receptors -- Sensors for FFA receptors -- Key questions for translation of FFA receptors from pharmacology to medicines -- Polymorphic variation in FFA receptors. Functions and consequences -- The role and future of FFA1 as a therapeutic target -- Gut hormone regulation and secretion via FFA1 and FFA4 -- The role of FFA2 and FFA3 in metabolic regulation -- Anti-inflammatory and insulin sensitizing effects of free fatty acid receptors -- Free Fatty Acid receptors and cancer. .
330   $aThis book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.
410  0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v236
606   $aPharmacology
606   $aHuman physiology
606   $aDiabetes
606   $aSystems biology
606   $aMedical biochemistry
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
606   $aDiabetes$3https://scigraph.springernature.com/ontologies/product-market-codes/H33045
606   $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L15010
606   $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005
615  0$aPharmacology.
615  0$aHuman physiology.
615  0$aDiabetes.
615  0$aSystems biology.
615  0$aMedical biochemistry.
615 14$aPharmacology/Toxicology.
615 24$aHuman Physiology.
615 24$aDiabetes.
615 24$aSystems Biology.
615 24$aMedical Biochemistry.
676   $a547.437
702   $aMilligan$b Graeme$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aKimura$b Ikuo$4edt$4http://id.loc.gov/vocabulary/relators/edt
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906   $aBOOK
912   $a9910164158903321
996   $aFree fatty acid receptors$91543391
997   $aUNINA