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010   $a3-319-41319-8
024 7 $a10.1007/978-3-319-41319-8
035   $a(CKB)3710000001041307
035   $a(DE-He213)978-3-319-41319-8
035   $a(MiAaPQ)EBC4791275
035   $a(PPN)198341784
035   $a(EXLCZ)993710000001041307
100   $a20170125d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMelanoma Development $eMolecular Biology, Genetics and Clinical Application /$fedited by Anja K. Bosserhoff
205   $a2nd ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (VIII, 447 p. 36 illus., 26 illus. in color.) 
311   $a3-319-41317-1 
320   $aIncludes bibliographical references and index.
327   $aClinicopathologic Overview of Melanoma -- Revisiting Epidermal Melanocytes: Regulation of Their Survival, Proliferation, and Function in Human Skin -- Melanoma Epidemiology -- Melanoma Genetics and Genomics -- Transcriptional Regulation in Melanoma -- MiRNAs in Malignant Melanoma -- Altered Signal Transduction Pathways in Melanoma -- Proteases in Melanoma -- Cell-cell contacts in melanoma and the tumor microenvironment -- Regulation of Apoptosis in Melanoma Cells: Critical Targets for Therapeutic Strategies -- Senescence -- Melanoma Stem Cells -- The Birth of Malignancy: Embryogenesis and Melanoma -- Tumor Microenvironment for Melanoma Cells -- Melanoma Model Systems -- New Approaches to Signaling -- Immune checkpoint inhibitors in melanoma define a new area in immunotherapy aiming for cure. .
330   $aThis book focuses on malignant melanoma, discussing the current state of scientific knowledge and providing insights into the underlying basic mechanisms, the molecular changes, genetics and genomics. Human Melanoma is a dangerous type of skin cancer affecting an increasing population, and a better understanding of its development will help in finding sophisticated targeted therapies. The second revised edition features the latest research findings and offers updates on the latest advances and potential novel melanoma therapies. It is a valuable resource for researchers and clinicians working in the fields of melanoma, cancer research and therapy as well as dermatology.
606   $aCancer research
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
615  0$aCancer research.
615 14$aCancer Research.
676   $a614.5999
702   $aBosserhoff$b Anja K$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910163043903321
996   $aMelanoma Development$92263857
997   $aUNINA