LEADER 05720nam 2200637 450 001 9910163018703321 005 20170821203053.0 010 $a3-318-02559-3 035 $a(CKB)3710000000251231 035 $a(EBL)3016637 035 $a(SSID)ssj0001378949 035 $a(PQKBManifestationID)11792754 035 $a(PQKBTitleCode)TC0001378949 035 $a(PQKBWorkID)11350549 035 $a(PQKB)10906004 035 $a(MiAaPQ)EBC3016637 035 $a(OCoLC)892512940 035 $a(SZ-BaSKA)261863 035 $a(PPN)195795288 035 $a(EXLCZ)993710000000251231 100 $a20141010h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aUnderstanding differences and disorders of sex development (DSD) /$fvolume editors O. Hiort, S. F. Ahmed 210 1$aBasel, Switzerland :$cS. Karger AG,$d2014. 210 4$dİ2014 215 $a1 online resource (312 p.) 225 1 $aEndocrine Development,$x1662-2979 ;$vVolume 27 300 $a"28 figures, 12 in color, and 26 tables, 2014"--Cover. 311 $a3-318-02558-5 320 $aIncludes bibliographical references and indexes. 327 $a""Cover""; ""Front Matter""; ""Contents""; ""Foreword""; ""Preface""; ""Concepts""; ""Gonadal Development""; ""Abstract""; ""Molecular Determinants of the Bipotential Gonad""; ""Molecular Determinants of Testis""; ""Molecular Determinants of the Ovary""; ""Conclusions""; ""Acknowledgements""; ""References""; ""The Masculinization Programming Window""; ""Abstract""; ""Reproductive Tract Development and Differentiation""; ""Internal Reproductive Organ Differentiation""; ""Differentiation of the External Genitalia""; ""Masculinization Programming Window in Males"" 327 $a""Clinical Implications of the MPW in Males""""Masculinization Programming Window in Females""; ""Anogenital Distance""; ""Modulation of Androgen Signal through Conditional Mutant Mice""; ""Conclusion""; ""References""; ""Androgen Action""; ""Abstract""; ""The Androgen Receptor""; ""Genomic Action of the Androgen Receptor""; ""Programming Androgen Actions""; ""Summary""; ""Acknowledgements""; ""References""; ""Technological Advances""; ""Steroid Biochemistry""; ""Abstract""; ""Steroidogenesis""; ""Measurement of Steroids in Body Fluids""; ""Defining of Specific Conditions"" 327 $a""Conclusions and Future Perspective""""References""; ""Next Generation Sequencing for Disorders of Sex Development""; ""Abstract""; ""Whole Genome or Exome?""; ""Not All Exome Datasets Are the Same""; ""Reporting Next Generation Sequencing Results""; ""Multiple Next Generation Sequencing Approaches to Understand Disorders of Sex Development""; ""Conclusions""; ""Acknowledgements""; ""References""; ""Advances in Neuroimaging""; ""Abstract""; ""Computed Tomography""; ""Magnetic Resonance Imaging""; ""Single Photon Emission Computed Tomography and Positron Emission Tomography"" 327 $a""Functional Magnetic Resonance Imaging""""Magnetic Resonance Spectroscopy""; ""Diffusion Tensor Imaging""; ""Sexual Dimorphism of Brain Structure and Function""; ""Structural Differences""; ""Functional Differences""; ""Neuroimaging in Disorders of Sex Development""; ""Conclusion""; ""References""; ""Imaging, Endoscopy and Diagnostic Surgery""; ""Abstract""; ""Techniques""; ""Imaging of the Gonads""; ""Imaging of the Sex Ducts and the Vagina""; ""Imaging of the Genitalia""; ""Very Rare Disorders of Sex Development""; ""Concluding Remarks""; ""References"" 327 $a""Fertility Issues in the Management of Patients with Disorders of Sex Development""""Abstract""; ""Dysgenetic Disorders of Sex Development""; ""46,XY Disorder of Sex Development due to Abnormal Testicular Hormone Synthesis or Action""; ""46,XX Disorders of Sex Development due to Excessive Androgen Exposure""; ""References""; ""Communication""; ""Disorders of Sex Development Peer Support""; ""Abstract""; ""History of Disorders of Sex Development Peer Support""; ""Value of Peer Support: Evaluation of the Evidence and Lessons to Be Learned"" 327 $a""Current Peer Support in Disorders of Sex Development"" 330 $aTen years ago a group of experts assembled in Chicago to develop a consensus on the management of conditions previously described as intersex. The consequences of this consensus have been far reaching, including a change in nomenclature, the development of greater collaboration across geographical boundaries, and a move towards greater involvement of patients and parents. Moreover, an international registry was established, as well as research and clinical networks. This book brings together a thorough overview on all these topics. Furthermore, the major technological advances in diagnostic genetic and biochemical capabilities over the past 10 years are outlined in detail. Offering a comprehensive update on various aspects of disorders of sex development (DSD), this book will be essential reading to all clinicians who are involved in delivering health care to patients with a DSD, as well as scientists involved in biomedical research related to DSD. 410 0$aEndocrine development ;$vVolume 27. 606 $aIntersexuality$xHistory 606 $aSex differentiation$xEndocrine aspects 615 0$aIntersexuality$xHistory. 615 0$aSex differentiation$xEndocrine aspects. 676 $a616.6/94 702 $aHiort$b O. 702 $aAhmed$b S. F. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910163018703321 996 $aUnderstanding differences and disorders of sex development (DSD)$92786443 997 $aUNINA