LEADER 05812nam 2200589 450 001 9910163017203321 005 20170822144530.0 010 $a3-318-05467-4 035 $a(CKB)3710000000446578 035 $a(EBL)3563951 035 $a(MiAaPQ)EBC3563951 035 $a(SZ-BaSKA)266637 035 $a(PPN)199159572 035 $a(OCoLC)911498995 035 $a(EXLCZ)993710000000446578 100 $a20150724h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aCalcium and bone disorders in children and adolescents /$fvolume editors, Jeremy Allgrove, Nick J. Shaw 205 $aSecond, revised edition. 210 1$aBasel, Switzerland :$cKarger,$d2015. 210 4$dİ2015 215 $a1 online resource (444 p.) 225 1 $aEndocrine Development,$x1421-7082 ;$vVolume 28 300 $aDescription based upon print version of record. 311 $a3-318-05466-6 320 $aIncludes bibliographical references at the end of each chapters and indexes. 327 $a""Cover ""; ""Front Matter ""; ""Contents""; ""Foreword""; ""Preface""; ""Voyages of Discovery""; ""Abstract""; ""Introduction""; ""Vitamin D and Rickets""; ""Parathyroid Hormone""; ""Calcitonin""; ""Parathyroid Hormone-Related Peptide""; ""Fibroblast Growth Factor 23""; ""References""; ""Physiology of Calcium, Phosphate, Magnesium and Vitamin D""; ""Abstract""; ""Introduction""; ""Calcium Physiology""; ""Control of Plasma Calcium""; ""Transmembrane Calcium Transport""; ""Transcellular Calcium Transport""; ""Magnesium Metabolism""; ""Paracellular Mechanisms of Cation Transport"" 327 $a""Phosphate Metabolism""""The Calcium Cascade""; ""The Calcium-Sensing Receptor Complex""; ""The Calcium-Sensing Receptor""; ""The G-Protein Second Messenger""; ""The Adaptor Protein""; ""The Parathyroid Glands""; ""The Parathyroid Hormone Receptors""; ""Intracellular Signalling""; ""The Target Organs""; ""Parathyroid Hormone-Related Peptide""; ""Calcitonin""; ""Alkaline Phosphatase""; ""Vitamin D Metabolism""; ""Summary and Conclusions""; ""References""; ""Physiology of Bone""; ""Abstract""; ""Introduction""; ""Skeletal Development""; ""Osteoblast Differentiation and Function"" 327 $a""Bone and Cartilage Matrix Collagens and Their Modifying Enzymes""""Glycoproteins and Proteoglycans in Bone""; ""Bone Mineralisation""; ""Osteocytes and Bone Lining Cells""; ""Hormones and Mineral Homeostasis""; ""The Nervous System and Bone""; ""Functional Adaptation of Bone to Load Bearing""; ""Healthy Bones for Life: Nutrition and Exercise in Bone Physiology""; ""Conclusions""; ""References""; ""Radiology of Osteogenesis Imperfecta, Rickets and Other Bony Fragility States""; ""Abstract""; ""Introduction""; ""Radiological Assessment of Bone Density and Quality"" 327 $a""Radiological Findings in Osteogenesis Imperfecta""""Overview of Features [8]""; ""Specific Features of Osteogenesis Imperfecta""; ""Spinal Disease in Osteogenesis Imperfecta""; ""Rickets and Related Disorders""; ""Basis for Radiological Findings in Vitamin D-Deficient Rickets""; ""Other Types of Rickets""; ""Radiology Findings in Other Bony Fragility States""; ""Conclusions""; ""References""; ""Bone Densitometry: Current Status and Future Perspective""; ""Abstract""; ""What is Bone Mineral Density?""; ""Assessment of Bone Density""; ""Measurement Principles"" 327 $a""Dual-Energy X-Ray Absorptiometry""""Volumetric Bone Density for Age""; ""Bone Mineral Content for Height""; ""Allometric Approach""; ""Regression Models""; ""Mechanostat Functional Model""; ""Diagnostic Potential of Dual-Energy X-RayAbsorptiometry""; ""Vertebral Fracture Assessment""; ""Quantitative Computed Tomography""; ""Diagnostic Potential of QuantitativeComputed Tomography""; ""Magnetic Resonance Imaging""; ""Summary and Guidelines""; ""References""; ""A Practical Approach to Hypocalcaemia in Children""; ""Abstract""; ""Introduction""; ""Physiological Response to Hypocalcaemia"" 327 $a""Signs and Symptoms of Hypocalcaemia"" 330 $aThere has been a rapid expansion of knowledge in the field of paediatric calcium and bone disorders over the past twenty years. Advances have been made in the underlying genetic basis for many conditions in conjunction with progress in bone density and geometry imaging and the development of new treatment options. The 2nd revised edition of ?Calcium and Bone Disorders in Children and Adolescents? presents up-to-date information on many aspects included in the 1st edition such as the physiology, pathology, diagnosis and management of numerous conditions including a chapter of case histories illustrating clinical aspects. New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. Providing a comprehensive update, this book is a useful clinical resource for paediatricians and specialists in endocrinology, metabolic bone disease, nephrology, rheumatology, radiology, orthopaedics and clinical genetics who may be faced with a child with a calcium and/or bone disorder. 410 0$aEndocrine development ;$vVolume 28. 606 $aBone diseases in children$vCase studies 606 $aCalcium metabolism disorders in children$vCase studies 615 0$aBone diseases in children 615 0$aCalcium metabolism disorders in children 676 $a618.92/71 702 $aAllgrove$b Jeremy 702 $aShaw$b Nick 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910163017203321 996 $aCalcium and bone disorders in children and adolescents$92597551 997 $aUNINA