LEADER 04974nam 2200589 450 001 9910162994103321 005 20170919165500.0 010 $a3-318-02789-8 035 $a(CKB)3820000000020352 035 $a(EBL)4466614 035 $a(SSID)ssj0001595225 035 $a(PQKBManifestationID)16291221 035 $a(PQKBTitleCode)TC0001595225 035 $a(PQKBWorkID)14809686 035 $a(PQKB)11320587 035 $a(MiAaPQ)EBC4466614 035 $a(SZ-BaSKA)270076 035 $a(PPN)199260842 035 $a(OCoLC)934036513 035 $a(EXLCZ)993820000000020352 100 $a20151008d2016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPuberty from bench to clinic $elessons for clinical management of pubertal disorders /$fvolume editors, Jean-Pierre Bourguignon, Anne-Simone Parent 210 1$aBasel ;$aNew York :$cKarger,$d2016. 215 $a1 online resource (276 p.) 225 1 $aEndocrine development,$x1421-7082 ;$vvolume 29 300 $aDescription based upon print version of record. 311 $a3-318-02788-X 320 $aIncludes bibliographical references and indexes. 327 $aThe emerging role of epigenetics in the regulation of female puberty / Lomniczi, A.; Ojeda, S.R -- Normal variation in pubertal timing : genetic determinants in relation to growth and adiposity / Willemsen, R.H.; Dunger, D.B -- Genetics of hypogonadotropic hypogonadism / Topaloglu, A.K.; Kotan, L.D -- Sexual precocity : genetic bases of central precocious puberty and autonomous gonadal activation / Macedo, D.B.; Silveira, L.F.G.; Bessa, D.S.; Brito, V.N.; Latronico, A.C -- Congenital hypogonadotropic hypogonadism : a trait shared by several complex neurodevelopmental disorders / de Roux, N.; Carel, J.-C.; Le?ger, J. (Paris) -- Animal modeling of early programming and disruption of pubertal maturation / Castellano, J.M.; Tena-Sempere, M -- Contemporary trends in onset and completion of puberty, gain in height and adiposity / Biro, F.M.; Kiess, W -- Consequences of early life programing by genetic and environmental influences : a synthesis regarding pubertal timing / Roth, C.L.; DiVall, S -- Nutritional disorders and pubertal disorders / Mun?oz-Calvo, M.T.; Argente, J -- Current changes in pubertal timing : revised vision in relation with environmental factors including endocrine disruptors / Parent, A.-S.; Franssen, D.; Fudvoye, J.; Pinson, A.; Bourguignon, J.-P -- Sex steroid and gonadotropin treatment in male delayed puberty / Howard, S.; Dunkel, L -- Sex steroid replacement therapy in female hypogonadism from childhood to young adulthood / Norjavaara, E.; Ankarberg-Lindgren, C.; Kristro?m, B -- Gonadotropin-releasing hormone agonist treatment in sexual precocity / Pienkowski, C.; Tauber, M -- Treatment of peripheral precocious puberty / Schoelwer, M.; Eugster, E.A -- Consultation for disordered puberty : what do adolescent medicine patients teach us? / Michaud, P.-A.; Ambresin, A.-E. 330 $aPuberty is a unique paradigm for the understanding of gene-environment interaction and developmental programming. Therefore, normal and abnormal pubertal development can be divided and examined in three sections: the role of genetic factors, the role of environmental factors (including nutrition) and therapeutic issues in disorders of puberty. Dealing with all of these sections and framed along current key concepts in pediatric endocrinology, experts share their view on critical issues such as weighting of genetic versus environmental factors or the impact of environmental factors in relation to critical periods in development. Not only showing the consensus and controversial issues in the various areas, each chapter presents lessons for clinical management in an attempt to link basic research, physiology and pathophysiology with the clinical management of pubertal disorders. Puberty from Bench to Clinic bridges up-to-date concepts from animal and human physiology and pathology towards a better understanding and management of pubertal disorders, making it a unique resource for researchers in the field of development and reproduction, clinical scientists and practitioners in neuro-, pediatric and adolescent endocrinology as well as gynecology. 410 0$aEndocrine development ;$vv. 29. 606 $aPuberty 606 $aGenerative organs$xAbnormalities$xGenetic aspects 606 $aGenerative organs$xAbnormalities$xEnvironmental aspects 615 0$aPuberty. 615 0$aGenerative organs$xAbnormalities$xGenetic aspects. 615 0$aGenerative organs$xAbnormalities$xEnvironmental aspects. 676 $a612.6 702 $aBourguignon$b J.-P 702 $aParent$b Anne-Simone 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910162994103321 996 $aPuberty from bench to clinic$92786565 997 $aUNINA