LEADER 05887nam 2200613 450 001 9910162994003321 005 20170822115009.0 010 $a3-318-05586-7 035 $a(CKB)3820000000020353 035 $a(EBL)4466618 035 $a(SSID)ssj0001645685 035 $a(PQKBManifestationID)16414061 035 $a(PQKBTitleCode)TC0001645685 035 $a(PQKBWorkID)14848377 035 $a(PQKB)11107501 035 $a(MiAaPQ)EBC4466618 035 $a(OCoLC)944327481 035 $a(SZ-BaSKA)271241 035 $a(PPN)197778704 035 $a(EXLCZ)993820000000020353 100 $a20151202d2016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSkin barrier function /$fvolume editor, Tove Agner 210 1$aBasel ;$aNew York :$cKarger,$d2016. 215 $a1 online resource (172 p.) 225 1 $aCurrent problems in dermatology,$x1421-5721 ;$vvolume 49 300 $aDescription based upon print version of record. 311 $a3-318-05585-9 320 $aIncludes bibliographical references and indexes. 327 $aCover; Front Matter; Contents; Preface; Section I: Basic Parameters; Filaggrin and Skin Barrier Function; Abstract; Filaggrin and the Skin Barrier; Clinical Studies; In vitro Models; Animal Models; Conclusion; Acknowledgment; References; Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients; Abstract; Lipid Properties in Healthy Stratum Corneum; Lipid Properties in Atopic Dermatitis; Enzymes Involved in Lipid Biosynthesis; Effect of FLG Mutations on Lipid Barrier Properties; Natural Moisturizing Factor and pH Levels 327 $aEffect of Inflammation on the Lipid Metabolism and Lipid Barrier PropertiesConcluding Remarks; References; Importance of Tight Junctions in Relation to Skin Barrier Function; Abstract; Tight Junctions and Their Proteins in Mammalian Skin; Barrier Function of Tight Junctions in the Skin; Nonbarrier Functions of Tight Junction Proteins in the Skin; Interaction of Tight Junctions with Other Barriers of the Skin - Importance of Tight Junctions for Skin Barrier Function; Tight Junctions as a Boundary between Microbial and Immunological Barriers; Conclusion; Acknowledgments; References 327 $aAntimicrobial Peptides, Infections and the Skin BarrierAbstract; Antimicrobial Peptides in the Epidermis; Antimicrobial Peptides and Impaired Barrier Function; Antimicrobial Peptides and Infections; Conclusion; Acknowledgment; References; Biological Variation in Skin Barrier Function: From A (Atopic Dermatitis) to X (Xerosis); Abstract; Biological Variation of the Skin Barrier with Age; Pathological Variations in Skin Barrier Function; Conclusion; References; Section II: External Factors Influencing Skin Barrier; Methods for the Assessment of Barrier Function; Abstract 327 $aTransepidermal Water LossBioengineering Methods for Skin Barrier Assessment (Other than Transepidermal Water Loss); Tape Stripping and Other Invasive Methods; Spectroscopic Methods, Molecular Imaging and Further Modern Methods; Irritants: Methods Used for Challenging Barrier Function; Conclusion; References; In vivo Raman Confocal Spectroscopy in the Investigation of the Skin Barrier; Abstract; Physical Basis of Raman Spectroscopy; In vivo Raman Confocal Spectroscopy of the Epidermal Barrier; Conclusion; References; Irritants and Skin Barrier Function; Abstract 327 $aIrritants and Skin Barrier HomeostasisNon-Invasive Bioengineering Methods; Conclusions; References; Skin Barrier Function and Allergens; Abstract; Normal Skin Barrier Function; Psoriasis; Atopic Dermatitis; Irritant Contact Dermatitis; Conclusion; Acknowledgment; References; Penetration through the Skin Barrier; Abstract; Percutaneous Penetration; Methodologies for Studying Percutaneous Penetration; Biological Factors Affecting Percutaneous Penetration; Physicochemical Characteristics Affecting Percutaneous Penetration; The Best Experimental Model?; References 327 $aSection III: Optimizing Skin Barrier Function 330 $aAlthough a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information. 410 0$aCurrent problems in dermatology ;$vv. 49. 606 $aSkin$xPhysiology 606 $aEpidermis$xPhysiology 615 0$aSkin$xPhysiology. 615 0$aEpidermis$xPhysiology. 676 $a612.7/9 702 $aAgner$b Tove 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910162994003321 996 $aSkin barrier function$92789145 997 $aUNINA