LEADER 01647nam 2200325Ia 450 001 996390762203316 005 20200824120803.0 035 $a(CKB)1000000000661426 035 $a(EEBO)2248522668 035 $a(UnM)99899341e 035 $a(UnM)99899341 035 $a(EXLCZ)991000000000661426 100 $a19961111d1647 uh | 101 0 $aeng 135 $aurbn||||a|bb| 200 10$aHis Maiesties most gracious declaration, left by him on his table at Hampton-Court, Novemb. 11. 1647$b[electronic resource] $eAnd directed to be communicated to the Speaker of the House of Lords pro tempore, and to be communicated unto the Lords and Commons in the Parliament of England at Westminster, and the Commissioners of the Parliament of Scotland, & to all my other subjects of what degree, condition or calling whatsoever 210 $aLondon $cprinted for Richard Royston$d1647 215 $a[2], 6, p 300 $aPresumably printed in London. However, Madan, II, 1959, states: There are several pieces printed in 1647 (usually 'Printed in the Yeare, 1647') which might be Oxford printing, but cannot be decisively stated to be such. 300 $aReproduction of original in the Henry E. Huntington Library. 330 $aeebo-0113 607 $aGreat Britain$xHistory$yCharles I, 1625-1649$vEarly works to 1800 701 $aCharles$cKing of England,$f1600-1649.$0793295 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bWaOLN 906 $aBOOK 912 $a996390762203316 996 $aHis Maiesties most gracious declaration, left by him on his table at Hampton-Court, Novemb. 11. 1647$92362364 997 $aUNISA LEADER 05125nam 2200469z- 450 001 9910161649203321 005 20210211 035 $a(CKB)3710000001041972 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55246 035 $a(oapen)doab55246 035 $a(oapen)55246 035 $a(EXLCZ)993710000001041972 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOntogeny and Phylogeny of Brain Barrier Mechanisms 210 $cFrontiers Media SA$d2016 215 $a1 online resource (358 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-810-3 330 $aThe brain functions within an internal environment that is determined and controlled by morphological structures and cellular mechanisms present at interfaces between the brain and the rest of the body. In vertebrates these interfaces are across cerebral blood vessels (blood-brain barrier) choroid plexuses (blood-cerebrospinal fluid barrier) and pia-arachnoid. There is a CSF-brain barrier in the neuroepithelium lining the ventricular system that is only present in embryos. There is now substantial evidence that many brain barrier mechanisms develop early and that in some cases they are functionally more active and even more specialized compared to adult barriers. Therefore barriers in developing brain should be viewed as adapted appropriately for the growing brain and not, as is still widely believed, immature. Considerable advances in our understanding of these barrier mechanisms have come from studies of the developing brain and invertebrates. A striking aspect, to be highlighted in this special edition, is that many of the molecular mechanisms in these very diverse species are similar despite differences in the cellular composition of the interfaces. This Frontiers Topic comprises articles in three sections: Original studies, Reviews and Myths & Misconceptions. Original articles provide new information on molecular and cellular barrier mechanisms in developing brains of primates, including human embryos (Brøchner et al., Ek et al., Errede et al.), rodents (Bauer et al., Liddelow, Strazielle & Ghersi-Egea, Saunders et al., Whish et al.), chick (Bueno et al.) and zebrafish (Henson et al.) as well as studies in drosophila (Hindle & Bainton, De Salvo et al., Limmer et al.). The Reviews section includes evolutionary perspectives of the blood-brain and blood-CSF barriers (Bueno et al., Bill & Korzh). There are also detailed reviews of the current state of understanding of different interfaces and their functional mechanisms in developing brain (Bauer et al., Strazielle & Gjersi-Egea, Liddelow, Richardson et al., Errede et al., Henson et al., Brøchner et al.) and in invertebrates (Hindle & Bainton, De Salvo et al., Limmer et al). Different aspects of the relationship between properties of the internal environment of the brain and its development are discussed. (Stolp & Molnar, Johansson, Prasongchean et al.). A neglected area, namely barriers over the surface of the brain during development is also covered (Brøchner et al.). Clinically related perspectives on barrier disruption in neonatal stroke are provided by Kratzer et al. and other aspects of dysfunction by Morretti et al. and by Palmeta et al. on the continuing problem of bilirubin toxicity. Progress in this field is hampered by many prevailing myths about barrier function, combined with methodologies that are not always appropriately selected or interpreted. These are covered in the Misconceptions, Myths and Methods section, including historical aspects and discussion of the paracellular pathway, a central dogma of epithelial and endothelial biology (Saunders et al.) and a review of markers used to define brain barrier integrity in development and in pathological conditions (Saunders et al.). Use of inappropriate markers has caused considerable confusion and unreliable interpretation in many published studies. Torbett et al. deal with the complexities of the new field of applying proteomics to understanding blood-brain barrier properties as do Huntley at al. with respect to applying modern high throughput gene expression methods (Huntley et al.). The Editorial summarizes the contributions from all authors. This includes mention of some the main unanswered but answerable questions in the field and what the impediments to progress may be. 606 $aNeurosciences$2bicssc 610 $aBlood-Brain Barrier 610 $ablood-CSF barrier 610 $aChoroid Plexus 610 $adevelopment 610 $aDrosophila 610 $aEfflux mechanisms 610 $aInflux mechanisms 610 $aTight Junctions 610 $azebra fish 615 7$aNeurosciences 700 $aShane A. Liddelow$4auth$01287763 702 $aHelen B. Stolp$4auth 702 $aNorman R. Saunders$4auth 906 $aBOOK 912 $a9910161649203321 996 $aOntogeny and Phylogeny of Brain Barrier Mechanisms$93020364 997 $aUNINA