LEADER 01177nas 2200433-a 450 001 996208029003316 005 20240112213020.0 011 $a1873-5924 035 $a(DE-599)ZDB2015922-5 035 $a(OCoLC)43323308 035 $a(CKB)954921421537 035 $a(CONSER)--2003238004 035 $a(EXLCZ)99954921421537 100 $a20000121a19919999 s-- - 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aReview of financial economics 210 $a[Amsterdam] $cNorth-Holland 210 31$a[Hoboken, N.J.?] :$cWiley 215 $a1 online resource 311 0 $a1058-3300 517 1 $aRFE 531 $aREV FINANC ECON 606 $aBusiness$vPeriodicals 606 $aEconomics$vPeriodicals 606 $aBusiness$2fast$3(OCoLC)fst00842262 606 $aEconomics$2fast$3(OCoLC)fst00902116 608 $aPeriodicals.$2fast 615 0$aBusiness 615 0$aEconomics 615 7$aBusiness. 615 7$aEconomics. 906 $aJOURNAL 912 $a996208029003316 996 $aReview of financial economics$91899256 997 $aUNISA LEADER 03934nam 2200481z- 450 001 9910161648903321 005 20210211 035 $a(CKB)3710000001041975 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44861 035 $a(oapen)doab44861 035 $a(EXLCZ)993710000001041975 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDeterminants of synaptic information transfer: From Ca2+ binding proteins to Ca2+ signaling domains 210 $cFrontiers Media SA$d2016 215 $a1 online resource (133 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-834-0 330 $aThe cytoplasmic free Ca2+ concentration ([Ca2+]i) is a key determinant of neuronal information transfer and processing. It controls a plethora of fundamental processes, including transmitter release and the induction of synaptic plasticity. This enigmatic second messenger conveys its wide variety of actions by binding to a subgroup of Ca2+ binding proteins (CaBPs) known as "Ca2+ sensors". Well known examples of Ca2+ sensors are Troponin-C in skeletal muscle, Synaptotagmin in presynaptic terminals, and Calmodulin (CaM) in all eukaryotic cells. Since the levels of [Ca2+]i directly influence the potency of Ca2+ sensors, the Ca2+ concentration is tightly controlled by several mechanisms including another type of Ca2+ binding proteins, the Ca2+ buffers. Prominent examples of Ca2+ buffers include Parvalbumin (PV), Calbindin-D28k (CB) and Calretinin (CR), although for the latter two Ca2+ sensor functions were recently also suggested. Ca2+ buffers are distinct from sensors by their purely buffering action, i.e. they influence the spatio-temporal extent of Ca2+ signals, without directly binding downstream target proteins. Details of their action depend on their binding kinetics, mobility, and concentration. Thus, neurons can control the range of action of Ca2+ by the type and concentration of CaBPs expressed. Since buffering strongly limits the range of action of free Ca2+, the structure of the Ca2+ signaling domain and the topographical relationships between the sites of Ca2+ influx and the location of the Ca2+ sensors are central determinants in neuronal information processing. For example, postsynaptic dendritic spines act to compartmentalize Ca2+ depending on their geometry and expression of CaBPs, thereby influencing dendritic integration. At presynaptic sites it has been shown that tight, so called nanodomain coupling between Ca2+ channels and the sensor for vesicular transmitter release increases speed and reliability of synaptic transmission. Vice versa, the influence of an individual CaBP on information processing depends on the topographical relationships within the signaling domain. If e.g. source and sensor are very close, only buffers with rapid binding kinetics can interfere with signaling. This Research Topic contains a collection of work dealing with the relationships between different [Ca2+]i controlling mechanisms in the structural context of synaptic sites and their functional implications for synaptic information processing as detailed in the Editorial. 517 $aDeterminants of synaptic information transfer 606 $aNeurosciences$2bicssc 610 $aCalcium 610 $acalcium buffer 610 $acalcium sensor 610 $adendritic integration 610 $alocalization 610 $aplasticity 610 $aSTED 610 $astorm 610 $atransmitter release 615 7$aNeurosciences 676 $a573.8/5 702 $aIsope$b Philippe$f1972- 702 $aSchmidt$b Hartmut$f1966- 702 $aWilms$b Christian D. 906 $aBOOK 912 $a9910161648903321 996 $aDeterminants of synaptic information transfer$93401864 997 $aUNINA