LEADER 00748nam0-22002651i-450- 001 990004916030403321 005 19990530 035 $a000491603 035 $aFED01000491603 035 $a(Aleph)000491603FED01 035 $a000491603 100 $a19990530g19609999km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $a<>publication of The Monk$eA Literary Event$e1796-1798$fAndrT Parreaux 210 $aParis$cLibrairie Marcel Didier$d1960. 215 $a202 p.$d24 cm 700 1$aParreaux,$bAndrt$0394644 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990004916030403321 952 $aSH 429$bFil. Mod.$fFLFBC 959 $aFLFBC 996 $aPublication of The Monk$9525375 997 $aUNINA LEADER 03621nam 2200445z- 450 001 9910161648803321 005 20210212 035 $a(CKB)3710000001041976 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57384 035 $a(oapen)doab57384 035 $a(EXLCZ)993710000001041976 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPutting the "why" back into bone "archytecture" 210 $cFrontiers Media SA$d2016 215 $a1 online resource (82 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-311-X 330 $aA large literature exists on trabecular and cortical bone morphology. The engineering performance of bone, implied from its 3d architecture, is often the endpoint of bone biology experiments, being clinically relevant to bone fracture. How and why does bone travel along its complex spatio-temporal trajectory to acquire its architecture? The question "why" can have two meanings. The first, "teleological - why is an architecture advantageous?" - is the domain of substantial biomechanical research to date. The second, "etiological - how did an architecture come about?" - has received far less attention. This Frontiers Bone Research Topic invited contributions addressing this "etiological why" - what mechanisms can coordinate the activity of bone forming and resorbing cells to produce the observed complex and efficient bone architectures? One mechanism is proposed - chaotic nonlinear pattern formation (NPF) which underlies - in a unifying way - natural structures as disparate as trabecular bone, swarms of birds flying or shoaling fish, island formation, fluid turbulence and others. At the heart of NPF is the fact that simple rules operating between interacting elements multiplied and repeated many times, lead to complex and structured patterns. This paradigm of growth and form leads to a profound link between bone regulation and its architecture: in bone "the architecture is the regulation". The former is the emergent consequence of the latter. Whatever mechanism does determine bone's developing architecture has to operate at the level of individual sites of formation and resorption and coupling between the two. This has implications as to how we understand the effect on bone of agents such as gene products or drugs. It may be for instance that the "tuning" of coupling between formation and resorption might be as important as the achievement of enhanced bone volume. The ten articles that were contributed to this Topic were just what we hoped for - a snapshot of leading edge bone biology research which addresses the question of how bone gets its shape. We hope that you find these papers thought-provoking, and that they might stimulate new ideas in the research into bone architecture, growth and adaptation, and how to preserve healthy bone from gestation and childhood until old age. 610 $aBone architecture 610 $aBone biomaterials 610 $aCortical bone 610 $acoupling 610 $aGrowth and Development 610 $aMechanotransduction 610 $amorphometry 610 $aNonlinear pattern formation 610 $aremodelling 610 $aTrabecular bone 700 $aPhil Salmon$4auth$01278855 702 $aDaniel Chappard$4auth 702 $aAndrew Anthony Pitsillides$4auth 906 $aBOOK 912 $a9910161648803321 996 $aPutting the "why" back into bone "archytecture"$93014024 997 $aUNINA