LEADER 03527nam 2200481z- 450 001 9910161648203321 005 20260129001020.0 035 $a(CKB)3710000001041982 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/41774 035 $a(oapen)doab41774 035 $a(EXLCZ)993710000001041982 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThe Bacterial Cell: Coupling between Growth, Nucleoid Replication, Cell Division and Shape 210 $cFrontiers Media SA$d2016 215 $a1 online resource (324 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-817-0 330 $aBacterial Physiology was inaugurated as a discipline by the seminal research of Maaløe, Schaechter and Kjeldgaard published in 1958. Their work clarified the relationship between cell composition and growth rate and led to unravel the temporal coupling between chromosome replication and the subsequent cell division by Helmstetter et al. a decade later. Now, after half a century this field has become a major research direction that attracts interest of many scientists from different disciplines. The outstanding question how the most basic cellular processes - mass growth, chromosome replication and cell division - are inter-coordinated in both space and time is still unresolved at the molecular level. Several particularly pertinent questions that are intensively studied follow: (a) what is the primary signal to place the Z-ring precisely between the two replicating and segregating nucleoids? (b) Is this coupling related to the structure and position of the nucleoid itself? (c) How does a bacterium determine and maintain its shape and dimensions? Possible answers include gene expression-based mechanisms, self-organization of protein assemblies and physical principles such as micro-phase separations by excluded volume interactions, diffusion ratchets and membrane stress or curvature. The relationships between biochemical reactions and physical forces are yet to be conceived and discovered. This e-book discusses the above mentioned and related questions. The book also serves as an important depository for state-of-the-art technologies, methods, theoretical simulations and innovative ideas and hypotheses for future testing. Integrating the information gained from various angles will likely help decipher how a relatively simple cell such as a bacterium incorporates its multitude of pathways and processes into a highly efficient self-organized system. The knowledge may be helpful in the ambition to artificially reconstruct a simple living system and to develop new antibacterial drugs. 517 $aBacterial Cell 606 $aMicrobiology (non-medical)$2bicssc 610 $aBacterial growth 610 $aCell Cycle 610 $aCell Division 610 $aCell envelope 610 $aChromosome replication 610 $aChromosome Segregation 610 $adivisome 610 $amodel system Escherichia coli 610 $anucleoid 610 $asize control 615 7$aMicrobiology (non-medical) 700 $aZaritsky$b Arieh$4auth$01891134 702 $aWoldringh$b Conrad L$4auth 702 $aMannik$b Jaan$4auth 906 $aBOOK 912 $a9910161648203321 996 $aThe Bacterial Cell: Coupling between Growth, Nucleoid Replication, Cell Division and Shape$94533888 997 $aUNINA