LEADER 03273nam 2200445z- 450 001 9910161647903321 005 20210211 035 $a(CKB)3710000001041985 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48664 035 $a(oapen)doab48664 035 $a(EXLCZ)993710000001041985 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aGlial Cells: Managers of Neuro-immunity 210 $cFrontiers Media SA$d2016 215 $a1 online resource (224 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-835-9 330 $aImmune responses within the brain are still scarcely explored. Nerve tissue damage is accompanied by the activation of glial cells, primarily microglia and astroglia, and such activation is responsible for the release of cytokines and chemokines that maintain the local inflammatory response and actively recruit lymphocytes and monocytes to the damaged areas. Theoretically, these responses are designed to repair the brain damage. However, alterations, or a chronic perpetuation of these responses may underlie a number of neuro-pathologies. It is thought that each inflammatory scenario within the brain have a specific biochemical footprint characterized by the release of determined cytokines, chemokines and growing factors able to define particular immunological responses. Alongside, glial cells transform their cell body, become larger and develop higher number of branches adopting an active morphological phenotype. These changes are related with the search of interactions with other cells, such as bystander resident cells of the brain parenchyma, but also cells homing from the blood stream. In this process, microglia and astrocytes communicates with other cells by the formation of specific intercellular connections that are still poorly understood. These interactions are complex and entail the arrangement of cytoskeletal compounds, secretory and phagocytic domains. In this particular crosstalk there is a two-way communication in which glial cells and target cells come together establishing interfaces with specific information exchange. This way, glial cells orchestrate the particular response recruiting cellular subsets within the central nervous system and organizing the resolution of the brain damage. In this Frontiers Research Topic, we compile a selection of articles unfolding diverse aspects of glial-derived inflammation, focused on neurodegenerative diseases and other nervous system disorders, with special emphasis on microglia/macrophages as leading actors managing neuro-immunity. 517 $aGlial Cells 606 $aNeurosciences$2bicssc 610 $aastroglia 610 $aglia 610 $aMicroglia 610 $aneuroimmunology 610 $aNeuroinflammation 610 $aT cells 615 7$aNeurosciences 700 $aGilles J. Guillemin$4auth$01317921 702 $aJeffrey M. Zirger$4auth 702 $aCarlos Barcia$4auth 702 $aJames F. Curtin$4auth 906 $aBOOK 912 $a9910161647903321 996 $aGlial Cells: Managers of Neuro-immunity$93033096 997 $aUNINA