LEADER 02329nam 2200445z- 450 001 9910161647303321 005 20210211 035 $a(CKB)3710000001041991 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48161 035 $a(oapen)doab48161 035 $a(EXLCZ)993710000001041991 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aFrontiers in the Pharmacological Manipulation of Intracellular cAMP Levels 210 $cFrontiers Media SA$d2016 215 $a1 online resource (191 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-815-4 330 $aCyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions. 606 $aPharmacology$2bicssc 610 $acAMP 610 $aCellular function 610 $acyclic adenosine monophosphate 610 $aDisease 610 $aHomeostasis 610 $apharmacological manipulation 610 $asignaling 610 $aTherapeutic applications 615 7$aPharmacology 700 $aGeorge S. Baillie$4auth$01291858 702 $aApostolos Zarros$4auth 702 $aFrank Christian$4auth 906 $aBOOK 912 $a9910161647303321 996 $aFrontiers in the Pharmacological Manipulation of Intracellular cAMP Levels$93022007 997 $aUNINA