LEADER 03397nam 2200481 450 001 9910157437903321 005 20180125150959.0 010 $a0-19-065126-1 010 $a0-19-065127-X 010 $a0-19-065125-3 035 $a(CKB)3710000001000650 035 $a(MiAaPQ)EBC4773438 035 $a(StDuBDS)EDZ0001615644 035 $a(PPN)19951044X 035 $a(EXLCZ)993710000001000650 100 $a20170110h20172017 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aImmunity $ethe evolution of an idea /$fAlfred I. Tauber 210 1$aNew York, NY :$cOxford University Press,$d2017. 215 $a1 online resource (329 pages) 300 $aPreviously issued in print: 2017. 311 $a0-19-091419-X 311 $a0-19-065124-5 320 $aIncludes bibliographical references and index. 327 $aCover; Immunity; Copyright; Dedication; Contents; Preface; Acknowledgments; Introduction; 1. A History of the Immune Self; 2. Whither Immune Identity?; 3. Individuality Revised; 4. Immune Cognition; 5. Eco-?immunology; 6. A New Biology?; Epilogue; Notes; References; Index 330 $aImmunology is the science of biological identity. Three key characteristics?individuality, identification, and immunity?together define immune identity, and as one notion changes meaning, so do the others. The story of this mutual dependence begins with the discovery of infectious diseases, when immunity, conceived as the response to invading pathogens, focused on the infected patient?later formalized as the ?immune self.? That orientation, signifying autonomy much in line with cultural norms of individuality, dominated twentieth-century immune theory. Although an effective idiom, the self construct has proven inadequate to account for the organism?s normal physiology and exchanges with the environment. When integrated into its larger ecology, immunity?s governing model shifts from defense to the more basic cognitive function of information processing that discerns benign from the toxic. The effector function (assimilate or eliminate) only follows identification of the immune object. Moreover, as a cognitive?communicative system (analogous to the brain), the immune system?s various roles assume their full expression only when the organism is considered in its total environment??internal? and ?external.? 330 $aFrom this perspective, beyond defending an insular individual, immunity accounts for the organism?s mutualist relationships that characterize the holobiont, where lines of demarcation are blurred. In response to this ecologically informed conception of the individual, the idea of immunity correspondingly widens. The implications of this revised configuration of immunity and its deconstructed notions of individuality and selfhood have wide significance for philosophers and life scientists working in immunology, ecology, and the cognitive sciences. 606 $aImmunology$xPhilosophy 615 0$aImmunology$xPhilosophy. 676 $a616.07/9 686 $aSCI075000$aMED044000$2bisacsh 700 $aTauber$b Alfred I.$052944 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910157437903321 996 $aImmunity$92597318 997 $aUNINA