LEADER 03852nam 2200601 450 001 9910156411503321 005 20170124111308.0 010 $a1-61504-740-9 024 7 $a10.4199/C00148ED1V01Y201612ISP072 035 $a(CKB)3710000000986517 035 $a(MiAaPQ)EBC4773097 035 $a(CaBNVSL)swl00407059 035 $a(OCoLC)969905972 035 $a(MOCL)201612ISP072 035 $a(EXLCZ)993710000000986517 100 $a20170116h20172017 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 14$aThe blood-brain barrier in health and disease /$fWilliam G. Mayhan, Denise M. Arrick 210 1$a[San Rafael, California] :$cMorgan & Claypool Life Sciences,$d2017. 210 4$dİ2017 215 $a1 online resource (77 pages) $cillustrations (some color) 225 0 $aColloquium Series on Integrated Systems Physiology: From Molecule to Function,$x2154-5626 ;$vLecture Number 72 300 $aPart of: Colloquium digital library of life sciences. 311 $a1-61504-739-5 320 $aIncludes bibliographical references. 327 $a1. Introduction -- 327 $a2. Characteristics of the blood-brain barrier -- 2.1 Development of the blood-brain barrier -- 2.2 Endothelial transport systems -- 327 $a3. Ultrastructural components of the blood-brain barrier -- 3.1 Tight junctional proteins -- 3.1.1 Occludin -- 3.1.2 Claudin -- 3.1.3 Junctional adhesion molecule -- 3.1.4 Accessory proteins -- 3.2 Adherens junctions -- 327 $a4. Cellular components of the blood-brain barrier -- 4.1 Astrocytes -- 4.2 Pericytes -- 4.3 Neurons -- 4.4 Microglia -- 327 $a5. Compromising the blood-brain barrier -- 5.1 Site of disruption of the blood-brain-barrier -- 5.2 Seizures/acute hypertension -- 5.3 Neuroinflammatory diseases -- 5.4 Diabetes -- 5.5 Traumatic brain injury -- 5.6 Cerebral ischemia/stroke -- 327 $a6. Summary -- References -- About the authors. 330 3 $aThe blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the level of adjacent endothelial cells, which are coupled to astrocytes, microglia, neurons and pericytes. The structure of this endothelial barrier is unique among endothelia of other organ systems and is composed of complexes made up of tight, gap and adherens junctions. In addition, it is the responsibility of the surrounding cellular elements to maintain the integrity of the junctional complexes and restrict the entry of substances from the blood into the brain. Changes in permeability of the BBB during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier. 410 0$aColloquium digital library of life sciences. 410 0$aColloquium series on integrated systems physiology ;$v# 72.$x2154-5626 606 $aBlood-brain barrier 606 $aBlood-brain barrier disorders 608 $aElectronic books. 615 0$aBlood-brain barrier. 615 0$aBlood-brain barrier disorders. 676 $a612.824 700 $aMayhan$b William G.$0865112 702 $aArrick$b Denise M. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910156411503321 996 $aThe blood-brain barrier in health and disease$91931011 997 $aUNINA