LEADER 04826nam 22007335 450 001 9910156336803321 005 20230831144559.0 024 7 $a10.1007/978-3-319-49284-1 035 $a(CKB)3710000000984056 035 $a(DE-He213)978-3-319-49284-1 035 $a(MiAaPQ)EBC4773255 035 $a(PPN)197455549 035 $a(EXLCZ)993710000000984056 100 $a20161222d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHow to Overcome the Antibiotic Crisis $eFacts, Challenges, Technologies and Future Perspectives /$fedited by Marc Stadler, Petra Dersch 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (XII, 496 p.) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v398 311 $a3-319-49282-9 311 $a3-319-49284-5 320 $aIncludes bibliographical references at the end of each chapters. 327 $aTackling threats and future problems of multidrug-resistant bacteria.-Emergence and spread of antimicrobial resistance: recent insights from bacterial population genomics -- Epidemiology of Staphylococcus aureus nasal carriage patterns in the community -- Diagnostics and resistance profiling of bacterial pathogens -- Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus suis.-Antibiotics and the intestinal microbiome: individual responses, resilience of the ecosystem and the susceptibility to infections -- Anti-virulence strategies to target bacterial infections -- Strategies to block bacterial pathogenesis by interference with motility and chemotaxis -- New horizons in the development of novel needle-free immunization strategies to increase vaccination efficacy -- History of antibiotics research -- Actinobacteria and Myxobacteria ? Two of the most important bacterial resources for novel antibiotics -- Exploitation of fungal biodiversity for discovery of novel antibiotics -- Strategies for the discovery and development of new antibiotics from natural products: Three Case Studies -- New structural templates for clinically validated and novel targets in antimicrobial drug research and development -- Synthesis of antibiotics -- Antibiotics clinical development and pipeline -- Anti-infectives in drug delivery?overcoming the Gram-negative bacterial cell envelope. 330 $aThis volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the ?bad bugs? are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike. 410 0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v398 606 $aMedical microbiology 606 $aDiseases 606 $aBacteria 606 $aPharmacology 606 $aMedicinal chemistry 606 $aVeterinary medicine 606 $aMedical Microbiology 606 $aDiseases 606 $aBacteria 606 $aPharmacology 606 $aMedicinal Chemistry 606 $aVeterinary Science 615 0$aMedical microbiology. 615 0$aDiseases. 615 0$aBacteria. 615 0$aPharmacology. 615 0$aMedicinal chemistry. 615 0$aVeterinary medicine. 615 14$aMedical Microbiology. 615 24$aDiseases. 615 24$aBacteria. 615 24$aPharmacology. 615 24$aMedicinal Chemistry. 615 24$aVeterinary Science. 676 $a610 702 $aStadler$b Marc$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDersch$b Petra$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910156336803321 996 $aHow to Overcome the Antibiotic Crisis$92512606 997 $aUNINA