LEADER 04704nam 22006375 450 001 9910155303003321 005 20200704040117.0 024 7 $a10.1007/978-3-319-48078-7 035 $a(CKB)3710000000964725 035 $a(DE-He213)978-3-319-48078-7 035 $a(MiAaPQ)EBC4748054 035 $a(PPN)197141412 035 $a(EXLCZ)993710000000964725 100 $a20161124d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGene Expression and Its Discontents $eThe Social Production of Chronic Disease /$fby Rodrick Wallace, Deborah Wallace 205 $a2nd ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (XIII, 344 p. 52 illus.) 311 $a3-319-48077-4 311 $a3-319-48078-2 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- 1. Toward new tools -- 2. Models of development -- 3. Groupoid symmetries -- 4. Epigenetic catalysis -- 5. Developmental disorders -- 6. An interim perspective -- 7. The obesity pandemic in the US -- 8. Coronary heart disease in the US. - 9. Cancer: a developmental perspective -- 10. Autoimmune disorders -- 11. Demoralization and obesity in Upper Manhattan -- 12. Death at an early age: AIDS and related mortality in New York City -- 13. Mental Disorders I: Western atomism and its culture-bound syndromes -- 14. Mental Disorders II: Psychopathology and sleep -- 15. Diabetes and Thyroid Cancer in Manhattan's Chinatown -- 16. Right-To-Work Laws and Alzheimer's Disease -- 17. Stress as an Environmental Exposure -- 18. Final Thoughts -- 19. Mathematical Appendix. 330 $aThis book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer?s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation. 606 $aHuman genetics 606 $aEpidemiology 606 $aBiochemistry 606 $aBioinformatics 606 $aPublic health 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aEpidemiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H63000 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aComputational Biology/Bioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/I23050 606 $aPublic Health$3https://scigraph.springernature.com/ontologies/product-market-codes/H27002 615 0$aHuman genetics. 615 0$aEpidemiology. 615 0$aBiochemistry. 615 0$aBioinformatics. 615 0$aPublic health. 615 14$aHuman Genetics. 615 24$aEpidemiology. 615 24$aBiochemistry, general. 615 24$aComputational Biology/Bioinformatics. 615 24$aPublic Health. 676 $a611.01816 676 $a599.935 700 $aWallace$b Rodrick$4aut$4http://id.loc.gov/vocabulary/relators/aut$0788350 702 $aWallace$b Deborah$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910155303003321 996 $aGene Expression and Its Discontents$92542069 997 $aUNINA