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024 7 $a10.1007/978-3-319-48418-1
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035   $a(DE-He213)978-3-319-48418-1
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100   $a20161210d2016      u|         0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aProteomics in Human Reproduction $eBiomarkers for Millennials /$fby Ashok Agarwal, Luna Samanta, Ricardo P. Bertolla, Damayanthi Durairajanayagam, Paula Intasqui
205   $a1st ed. 2016.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016.
215   $a1 online resource (XV, 124 p. 9 illus.)
225 1 $aSpringerBriefs in Reproductive Biology,$x2194-4253
311   $a3-319-48416-8 
320   $aIncludes bibliographical references.
327   $aIntroduction -- Proteomics -- Proteomics and Male Infertility -- Role of Proteomics in Female Infertility -- Proteomics in Assisted Reproduction -- Challenges of Proteomic Studies in Human Reproduction -- What Does the Future Hold? -- Conclusions.
330   $aThis Brief explores the use of proteomics as a tool for biomarker discovery in human reproduction and summarizes current findings and trends of proteomic studies in both male and female infertility. This simplifies this important but complex topic and equips the novice reader with sufficient background information on the use of proteomics in human reproduction. The up-to-date scenario on proteomic investigations will also appeal to researchers and post graduate students looking to keep abreast with the latest developments in reproductive research. This review summarizes current findings of contemporary proteomic studies on infertility in both males and females with various reproductive pathologies, and its use in predicting the outcome of assisted reproduction. In human reproduction, the search for biomarkers via proteomics is a fast-evolving approach that involves the analysis of proteins in the reproductive tissues and fluids, such as the male gametes, seminal plasma, ovarian and endometrial tissue, and follicular and uterine fluid. By comparing the protein profile of a healthy, fertile individual against that of an infertile individual, the differentially expressed proteins may give an indication to certain proteins that could serve as useful biomarkers that are related to infertility. As proteomic studies continue to unravel the dynamic proteome behind various infertility conditions, there is potential for the discovery of prognostic markers that could ultimately help in both natural and assisted human reproduction.
410  0$aSpringerBriefs in Reproductive Biology,$x2194-4253
606   $aReproductive medicine
606   $aProteomics
606   $aBioinformatics
606   $aReproductive Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H56002
606   $aProteomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L1403X
606   $aBioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15001
615  0$aReproductive medicine.
615  0$aProteomics.
615  0$aBioinformatics.
615 14$aReproductive Medicine.
615 24$aProteomics.
615 24$aBioinformatics.
676   $a572.6
700   $aAgarwal$b Ashok$4aut$4http://id.loc.gov/vocabulary/relators/aut$0789686
702   $aSamanta$b Luna$4aut$4http://id.loc.gov/vocabulary/relators/aut
702   $aBertolla$b Ricardo P$4aut$4http://id.loc.gov/vocabulary/relators/aut
702   $aDurairajanayagam$b Damayanthi$4aut$4http://id.loc.gov/vocabulary/relators/aut
702   $aIntasqui$b Paula$4aut$4http://id.loc.gov/vocabulary/relators/aut
801  0$bMiAaPQ
801  1$bMiAaPQ
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906   $aBOOK
912   $a9910155274903321
996   $aProteomics in Human Reproduction$92526683
997   $aUNINA