LEADER 03169oam 2200505I 450 001 9910155108503321 005 20240505171906.0 010 $a1-315-35180-3 010 $a1-315-36883-8 010 $a1-4987-4549-0 024 7 $a10.1201/9781315368832 035 $a(CKB)3710000000973137 035 $a(MiAaPQ)EBC4769147 035 $a(OCoLC)966610155 035 $a(BIP)63734737 035 $a(BIP)55667919 035 $a(EXLCZ)993710000000973137 100 $a20180331h20172017 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aTherapeutic applications of adenoviruses /$fedited by Philip Ng and Nicola Brunetti-Pierri 205 $a1st ed. 210 1$aBoca Raton :$cCRC Press, Taylor & Francis,$d[2017] 210 4$dİ2017 215 $a1 online resource (257 pages) $cillustrations, tables 225 1 $aGene and Cell Therapy 311 08$a1-4987-4548-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aChapter 1. Adenovirus biology and development as a gene delivery vector / Leslie A. Nash and Robin J. Parks -- Chapter 2. Innate and adaptive immune responses to adenovirus / Svetlana Atasheva and Dmitry M. Shayakhmetov -- Chapter 3. Helper-dependent adenoviral vectors for cell and gene therapy / Nicola Brunetti-Pierri and Philip Ng -- Chapter 4. Chemical and combined genetic and chemical modifications of adenovirus vector capsids to overcome barriers for in vivo vector delivery / Florian Kreppel -- Chapter 5. Design and applications of adenovirus-based hybrid vectors / Anja Ehrhardt and Wenli Zhang -- Chapter 6. Adenovirus vectors for genome editing involving engineered endonucleases / Kamola Saydaminova, Maximilian Richter, Philip Ng, Anja Ehrhardt, Andr Lieber -- Chapter 7. Adenoviruses for vaccination / Michael A. Barry -- Chapter 8. Use of oncolytic adenoviruses for cancer therapy / Cristian Capasso, Manlio Fusciello, Erkko Yl'sm?ki, Vincenzo Cerullo. 330 $aAdenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the Life Sciences interested in therapeutic applications of adenoviruses. This book reviews the life history and immune responses to adenoviruses and summarizes various therapies implemented with the use of adenoviruses. 410 0$aGene and cell therapy series. 606 $aAdenoviruses 615 0$aAdenoviruses. 676 $a616.92507 702 $aNg$b Philip$f1968- 702 $aBrunetti-Pierri$b Nicola 801 0$bFlBoTFG 801 1$bFlBoTFG 906 $aBOOK 912 $a9910155108503321 996 $aTherapeutic applications of adenoviruses$92243641 997 $aUNINA