LEADER 03540nam 2200517 450 001 9910155004903321 005 20200520144314.0 010 $a1-56368-671-6 035 $a(CKB)4340000000023083 035 $a(MiAaPQ)EBC4760888 035 $a(OCoLC)965828505 035 $a(MdBmJHUP)muse53988 035 $a(Au-PeEL)EBL4760888 035 $a(CaPaEBR)ebr11312865 035 $a(EXLCZ)994340000000023083 100 $a20161102h20162016 uy| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aDeaf epistemologies, identity, and learning $ea comparative perspective /$fGoedele A. M. De Clerck 210 1$aWashington :$cGallaudet University Press,$d[2016] 210 4$dİ2016 215 $a1 online resource (283 pages) $cillustrations 225 1 $aDeaf education series ;$v5 311 $a1-56368-670-8 320 $aIncludes bibliographical references and index. 330 $a"Goedele A. M. De Clerck presents cross-cultural comparative research that examines and documents where deaf flourishing occurs and how it can be advanced. She spotlights collective and dynamic resources of knowledge and learning; the coexistence of lived differences; social, linguistic, cultural, and psychological capital; and human potential and creativity. Deaf Epistemologies, Identity, and Learning argues for an inclusive approach to the intrinsic human diversity in society, education, and scholarship, and shows how emotions of hope, frustration, and humiliation contribute to the construction of identity and community. De Clerck also considers global to local dynamics in deaf identity, deaf culture, deaf education, and deaf empowerment. She presents empirical research through case studies of the emancipation processes for deaf people in Flanders (a region of Belgium), the United States (specifically, at Gallaudet University in Washington, DC), and the West African nation of Cameroon. These three settings illuminate different phases of emancipation in different contexts, and the research findings are integrated into a broader literature review and subjected to theoretical reflection. De Clerck's anthropology of deaf flourishing draws from her critical application of the empowerment paradigm in settings of daily life, research, leadership, and community work, as she explores identity and well-being through an interdisciplinary lens. This work is centered around practices of signed storytelling and posits learning as the primary access and pathway to culture, identity, values, and change. Change driven by the learning process is considered an awakening--and through this awakening, the deaf community can gain hope, empowerment, and full citizenship. In this way, deaf people are allowed to shape their histories, and the result is the elevation of all aspects of deaf lives around the world"--$cProvided by publisher. 410 0$aDeaf education series ;$v5. 606 $aDeaf$xEducation$vCross-cultural studies 606 $aDeaf$xServices for$vCross-cultural studies 606 $aIdentity (Psychology) 608 $aElectronic books. 615 0$aDeaf$xEducation 615 0$aDeaf$xServices for 615 0$aIdentity (Psychology) 676 $a305.9/082 700 $aDe Clerck$b Goedele$01048088 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910155004903321 996 $aDeaf epistemologies, identity, and learning$92476099 997 $aUNINA LEADER 03999nam 2200445z- 450 001 9910261134603321 005 20210211 035 $a(CKB)4100000002484746 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44997 035 $a(oapen)doab44997 035 $a(EXLCZ)994100000002484746 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDiacylglycerol Kinase Signalling 210 $cFrontiers Media SA$d2017 215 $a1 online resource (96 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-335-9 330 $aDiacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DG), catalyzing its conversion into phosphatidic acid (PA). This reaction attenuates membrane DG levels, limiting the localization/activation of signaling proteins that bind this lipid. Initially recognized as modulators of classical and novel PKC family members, the function of the DGK has further expanded with the identification of novel DG effectors including Ras Guanyl nucleotide-releasing proteins (RasGRP) and chimaerin Rac GTPases. The product of the DGK reaction, PA, is also a signaling lipid that mediates activation of multiple proteins including the mammalian target of rapamycin (mTOR). The DGK pathway thus modulates two lipids with important signaling properties that are also key intermediates in lipid metabolism and membrane trafficking. The DGK family in eukaryotes comprises 10 different members grouped into five different subfamilies characterized by the presence of particular regulatory motifs. These regions allow the different DGK isoforms to establish specific complexes and/or to be recruited to specific subcellular compartments. The subtle regulation of DG and PA catalyzed byspecific DGKs is sensed by a restricted set of molecules, providing the means for spatio-temporal regulation of signals in highly specialized cell systems. In the recent years, multiple studies have unveiled the functions of specific isoforms, their mechanisms of regulation and their participation in different pathways leading to and from DG and PA. Animal models have greatly helped to understand the specialized contribution of DGK mediated signals, particularly in the immune and central nervous systems. Mice deficient for individual DGK isoforms show defects in T and B cell functions, dendritic spine maintenance, osteoclast and mechanical-induced skeletal muscle formation. Studies in flies and worms link DGK mediated DAG metabolism with mTOR- mediated regulation of lifespan and stress responses. In plants DGK mediated PA formation contributes to plant responses to environmental signals. Aberrant DGK function has been recently associated with pathological states, an expected consequence of the essential role of these enzymes in the regulation of multiple tissue and systemic functions. DGK mutations/deletions have been related to human diseases including diabetes, atypical hemolytic-uremic syndrome, Parkinson disease and bipolar disorders. On the contrary DGK upregulation emerges as a non-oncogenic addition of certain tumors and represents one of the main mechanism by which cancer evades the immune attack. As a result, the DGK field emerges an exciting new area of research with important therapeutic potential. 606 $aBiology, life sciences$2bicssc 610 $acytotoxic T cells 610 $aimmune system 610 $aimmunotherapy of cancer 610 $alipid signaling 610 $asynaptic plasticity (LTP/LTD) 610 $asynaptic transmission 610 $aT cell receptor 610 $atolerance 615 7$aBiology, life sciences 700 $aAndrea Graziani$4auth$01320420 702 $aFumio Sakane$4auth 702 $aIsabel Merida$4auth 906 $aBOOK 912 $a9910261134603321 996 $aDiacylglycerol Kinase Signalling$93034285 997 $aUNINA