LEADER 01074nas 2200385 c 450 001 996321389403316 005 20200217111312.0 011 $a2559-4656 035 $a(CKB)3790000000116296 035 $a(OCoLC)802670406 035 $a(DE-101)1024284263 035 $a(DE-599)ZDB2673231-2 035 $a(EXLCZ)993790000000116296 100 $a20120717a20069999 |y | 101 0 $arum 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aANADISS$erevue du Centre de Recherche Analyse du Discours : journal of the Discourse Analysis Research Centre 210 31$aSuceava$cEditura Universita?t?ii Suceava$d2006- 300 $aErscheint halbja?hrlich 300 $aGesehen am 31.05.2018 311 $a1842-0400 608 $aZeitschrift$2gnd-content 676 $a070 676 $a400 686 $aOST$qDE-12$2fid 801 0$b0355 801 1$bDE-101 801 2$b8007 906 $aJOURNAL 912 $a996321389403316 996 $aANADISS$91961658 997 $aUNISA LEADER 03702nam 22004815 450 001 9910154671503321 005 20200705203729.0 024 7 $a10.1007/978-1-4939-6460-4 035 $a(CKB)3710000000964604 035 $a(DE-He213)978-1-4939-6460-4 035 $a(MiAaPQ)EBC4747261 035 $a(PPN)19713467X 035 $a(EXLCZ)993710000000964604 100 $a20161123d2016 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFrontiers in Cancer Research $eEvolutionary Foundations, Revolutionary Directions /$fedited by Carlo C. Maley, Mel Greaves 205 $a1st ed. 2016. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2016. 215 $a1 online resource (XIV, 258 p. 28 illus., 17 illus. in color.) 311 $a1-4939-6458-5 311 $a1-4939-6460-7 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a1. The Evolutionary Foundations of Cancer Research -- 2. The Role of Theory in Cancer Research -- 3. Population Genetics of Neoplasms -- 4. Diversity in Neoplasms -- 5. How do Mutant Clones Expand in Normal Tissue? -- 6. Cancer Stem Cells in Tumor Evolution -- 7. Measuring Rather than Imagining Somatic Cell Selection and Clonal Evolution -- 8. The Darwinian Dynamics of Motility and Metastasis -- 9. Applying Evolutionary Principles to Cancer Therapy -- 10. Mismatches with Our Ancestral Environments and Cancer Risk -- 11. The Evolution of Cancer Suppression Mechanisms -- 12. Epilogue: How can we Thwart the Evolutionary Resilience of Cancer?. 330 $aThis is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention. . 606 $aCancer research 606 $aPharmacology 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 615 0$aCancer research. 615 0$aPharmacology. 615 14$aCancer Research. 615 24$aPharmacology/Toxicology. 676 $a614.5999 702 $aMaley$b Carlo C$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGreaves$b Mel$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910154671503321 996 $aFrontiers in Cancer Research$92524212 997 $aUNINA