LEADER 04800nam 22005895 450 001 9910153304603321 005 20200705145420.0 010 $a3-319-40854-2 024 7 $a10.1007/978-3-319-40854-5 035 $a(CKB)3710000000961019 035 $a(DE-He213)978-3-319-40854-5 035 $a(MiAaPQ)EBC4746690 035 $a(PPN)197138217 035 $a(EXLCZ)993710000000961019 100 $a20161121d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aIncreasing the Therapeutic Ratio of Radiotherapy$b[electronic resource] /$fedited by Philip J. Tofilon, Kevin Camphausen 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2017. 215 $a1 online resource (VIII, 280 p. 41 illus., 34 illus. in color.) 225 1 $aCancer Drug Discovery and Development,$x2196-9906 311 $a3-319-40852-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPart 1. Molecular Targets -- 1. Improving the therapeutic ratio of radiotherapy by targeting the DNA Damage Response -- 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity -- 3. Histone Deacetylase Inhibitors and Tumor Radiosensitization -- 4. Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy -- Part 2. Microenvironment -- 5. Application of Functional Molecular Imaging in Radiation Oncology -- 6. Remodeling the Irradiated Tumor Microenvironment: The 5th R of Radiobiology? -- 7. Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation -- Part 3. Clinical -- 8. Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules -- 9. Novel Imaging for Treatment Planning or Tumor Response -- 10. Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles -- Index. 330 $aCurrent cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic. 410 0$aCancer Drug Discovery and Development,$x2196-9906 606 $aCancer research 606 $aRadiotherapy 606 $aDrug resistance 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aRadiotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H29056 606 $aDrug Resistance$3https://scigraph.springernature.com/ontologies/product-market-codes/B16020 615 0$aCancer research. 615 0$aRadiotherapy. 615 0$aDrug resistance. 615 14$aCancer Research. 615 24$aRadiotherapy. 615 24$aDrug Resistance. 676 $a616.9940642 702 $aTofilon$b Philip J$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCamphausen$b Kevin$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910153304603321 996 $aIncreasing the Therapeutic Ratio of Radiotherapy$91758865 997 $aUNINA